Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells.

Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Research Abstract Details 

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Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Abstract Text:

Saravanan Thiyagarajan,Neehar Bhatia,Shannon Reagan-Shaw,Diana Cozma,Andrei Thomas-Tikhonenko,Nihal Ahmad,Vladimir S Spiegelman,

Aberrant activation of the Hedgehog (Hh) signaling pathway has been reported in various cancer types including prostate cancer. The GLI2 transcription factor is a primary mediator of Hh signaling. However, its relative contribution to development of prostate tumors is poorly understood. To establish the role of GLI2 in maintaining the tumorigenic properties of prostate cancer cells, we developed GLI2-specific small hairpin RNA. Knockdown of GLI2 in these cells resulted in significant down-regulation of the Hh signaling pathway, followed by inhibition of colony formation, anchorage-independent growth, and growth of xenografts in vivo. Conversely, ectopic expression of Gli2 in nontumorigenic prostate epithelial cells resulted in accelerated cell cycle progression, especially transition through G(2)-M, and augmented proliferation. Altogether, our findings suggest that GLI2 plays a critical role in the malignant phenotype of prostate cancer cells, and GLI2 may potentially become an attractive therapeutic target for the treatment of prostate cancer.

Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Publishing Authors By Initials

S Thiyagarajan,N Bhatia,S Reagan-Shaw,D Cozma,A Thomas-Tikhonenko,N Ahmad,VS Spiegelman,

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Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 67

Page Numbers: 10642-6

Journal Abbreviation: Cancer Res.

ISSN: 1538-7445

DAY: 15

MONTH: Nov

YEAR: 2007

Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

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Grant and Affiliation Information for Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells.

AFFILIATION: Department of Dermatology and Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA.

Country: United States

AGENCY: United States NCI

GRANT: 1R01CA92900

ACRONYM: CA

MEDLINETA: Cancer Res

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