Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae.

Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae. Abstract Text:

Julie Nieminen,Christian St-Pierre,Pampa Bhaumik,Françoise Poirier,Sachiko Sato,

Pneumonia can be caused by a variety of pathogens, among which Streptococcus pneumoniae causes one of the most common forms of community-acquired pneumonia. Depending on the invading pathogen, the elements of the immune response triggered will vary. For most pathogens, such as Escherichia coli, neutrophil recruitment involves a well-described family of adhesion molecules, beta(2)-integrins. In the case of streptococcal pneumonia, however, neutrophil recruitment occurs mainly through a beta(2)-integrin-independent pathway. Despite decades of research on this issue, the adhesion molecules involved in neutrophil recruitment during lung infection by S. pneumoniae have not been identified. We have previously shown that galectin-3, a soluble mammalian lectin, can be found in lungs infected by S. pneumoniae, but not by E. coli, and can mediate the adhesion of neutrophils on the endothelial cell layer, implying its role in the recruitment of neutrophils to lungs infected with S. pneumoniae. In this study, using galectin-3 null mice, we report further evidence of the involvement of this soluble lectin in the recruitment of neutrophils to S. pneumonia-infected lungs. Indeed, in the absence of galectin-3, lower numbers of leukocytes, mainly neutrophils, were recruited to the infected lungs during infection by S. pneumoniae. In the case of beta(2)-integrin-dependent recruitment induced by lung infection with E. coli, the number of recruited neutrophils was not reduced. Thus, taken together, our data suggest that galectin-3 plays a role as a soluble adhesion molecule in the recruitment of neutrophils to lungs infected by S. pneumoniae, which induces beta(2)-integrin-independent migration.

Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae. Publishing Authors By Initials

J Nieminen,C St-Pierre,P Bhaumik,F Poirier,S Sato,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 180

Page Numbers: 2466-73

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Feb

YEAR: 2008

Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae.

AFFILIATION: Glycobiology Laboratory, Research Center for Infectious Diseases, Faculty of Medicine, Laval University, Québec, Canada.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae Related Publications

• Age related changes in the distribution of laryngeal glands in the human adult larynx.
• Anti-eosinophil peroxidase antibodies detected in patients with primary biliary cirrhosis.
• Assessment of bull fertility using a mucus penetration test and a human chorionic gonadotrophin stimulation test.
• Colonic mucosal lesions associated with long-term administration of non-steroidal anti-inflammatory drugs.
• Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid.
• Differences in acetazolamide vasoreactivity in patients with acute and chronic occlusion of the internal carotid artery.
• Effect of low-molecular-weight heparin on the commitment of bone marrow cells to liver sinusoidal endothelial cells in CCl(4)-induced liver injury.
• Effects of gonadotropin releasing hormone and prostaglandin F(2)alpha on the reproductive performance in postpartum cows.
• Exacerbation of dietary steatohepatitis and fibrosis in obese, diabetic KK-A(y) mice.
• Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: its relationship with a new morphological classification of cholangiocarcinoma.
• Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients.
• Expression of mucin antigens in human cancers and its relationship with malignancy potential.
• Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: its relationship with the biological behavior of the tumor.
• Hepatic steatosis is a predictor of poor response to interferon alpha-2b and ribavirin combination therapy in Japanese patients with chronic hepatitis C.
• Immunohistochemical study of mucin carbohydrates and core proteins in human pancreatic tumors.
• Infective Endocarditis Associated with Sjogren's Syndrome.
• Isokinetic external rotation strength of shoulder : correlation with age and muscle size.
• MUC-1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas.
• MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients.
• Mechanism by which Bombyx mori hemocytes recognize microorganisms: direct and indirect recognition systems for PAMPs.
• Modeling of daily operation in proton radiotherapy by Monte Carlo method.
• Mucin antigen expression in gastric carcinomas of young and old adults.
• Prostaglandin E(2) levels in uterine tissues and its relationship with uterine and luteal progesterone during the estrous cycle in dairy cows.
• Reconstruction of scalp and cranium defect utilizing latissimus dorsi musculocutaneous and serratus anterior muscle free flaps with interpositional anastomosis of T-shaped flap artery: case report.
• Second messenger systems mediating sex pheromone and amino Acid sensitivity in goldfish olfactory receptor neurons.
• Study on the appearance of the cavity in the corpus luteum of cows by using ultrasonic scanning.
• The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms.
• The role of leptin in progression of non-alcoholic fatty liver disease.
• Voglibose potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen by inducing CYP2E1 in rats.
• [Development and operation of cultured cell experiment with TR-IA sounding rocket]