Role of fibroblast growth factor receptor signaling in kidney development.

Role of fibroblast growth factor receptor signaling in kidney development. Research Abstract Details 

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Role of fibroblast growth factor receptor signaling in kidney development. Abstract Text:

Carlton M Bates,

Fibroblast growth factor receptors (Fgfrs) are expressed in the ureteric bud and metanephric mesenchyme of the developing kidney. Furthermore, in vitro and in vivo studies have shown that exogenous fibroblast growth factors (Fgfs) increase growth and maturation of the metanephric mesenchyme and ureteric bud. Deletion of fgf7, fgf10, and fgfr2IIIb (the receptor isoform that binds Fgf7 and Fgf10) in mice lead to smaller kidneys with fewer collecting ducts and nephrons. Overexpression of a dominant negative receptor isoform in transgenic mice has revealed more striking defects including renal aplasia or severe dysplasia. Moreover, deletion of many fgf ligands and receptors in mice results in early embryonic lethality, making it difficult to determine their roles in kidney development. Recently, conditional targeting approaches revealed that deletion of fgf8 from the metanephric mesenchyme interrupts nephron formation. Furthermore, deletion of fgfr2 from the ureteric bud resulted in both ureteric bud branching and stromal mesenchymal patterning defects. Deletion of both fgfr1 and fgfr2 in the metanephric mesenchyme resulted in renal aplasia, characterized by defects in metanephric mesenchyme formation and initial ureteric bud elongation and branching. Thus, Fgfr signaling is critical for growth and patterning of all renal lineages at early and later stages of kidney development.

Role of fibroblast growth factor receptor signaling in kidney development. Publishing Authors By Initials

CM Bates,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

PUBMED ID PMID:

MEDLINE DATE:

Role of fibroblast growth factor receptor signaling in kidney development. Journal Published:

PUBLICATION TYPE: Review

Journal: Pediatric nephrology (Berlin, Germany)

VOLUME: 22

Page Numbers: 343-9

Journal Abbreviation: Pediatr. Nephrol.

ISSN: 0931-041X

DAY: 24

MONTH: 08

YEAR: 2006

Role of fibroblast growth factor receptor signaling in kidney development. Information

Number of References: 37

LANGUAGE: eng

NlmUniqueID: 8708728

Role of fibroblast growth factor receptor signaling in kidney development. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Role of fibroblast growth factor receptor signaling in kidney development. Information

Substance Name: Receptor, Fibroblast Growth Factor, Type

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Role of fibroblast growth factor receptor signaling in kidney development.

AFFILIATION: Center for Cell and Developmental Biology, Columbus Children's Research Institute, 700 Children's Drive, Columbus, OH 43205, USA. batesc@pediatrics.ohio-state.edu

Country: Germany

AGENCY: United States NIDDK

GRANT: R01 DK070030-01

ACRONYM: DK

MEDLINETA: Pediatr Nephrol

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