Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake.

Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake. Abstract Text:

Micheline M de Resende,Sandra L Amaral,Diane H Munzenmaier,Andrew S Greene,

Angiogenesis, under normal conditions, is a tightly regulated balance between pro- and antiangiogenic factors. The goal of this study was to investigate the mechanisms involved in the control of the skeletal muscle angiogenic response induced by electrical stimulation during the suppression of plasma renin activity (PRA) with a high-salt diet. Rats fed 0.4% or 4% salt diets were exposed to electrical stimulation for 7 days. The tibialis anterior (TA) muscles from stimulated and unstimulated hindlimbs were removed and prepared for gene expression analysis, CD31-terminal deoxynucleotide transferase-mediated dUTP nick-end labeling (TUNEL) double-staining assay, and Bcl-2 and Bax protein expression by Western blot. Rats fed a low-salt diet showed a dramatic angiogenesis response in the stimulated limb compared with the unstimulated limb. This angiogenesis response was significantly attenuated when rats were placed on a high-salt diet. Microarray analysis showed that in the stimulated limb of rats fed a low-salt diet many genes related to angiogenesis were upregulated. In contrast, in rats fed a high-salt diet most of the genes upregulated in the stimulated limb function in apoptosis and cell cycle arrest. Endothelial cell apoptosis, as analyzed by CD31-TUNEL staining, increased by fourfold in the stimulated limb compared with the unstimulated limb. There was also a 48% decrease in the Bcl-2-to-Bax ratio in stimulated compared with unstimulated limbs of rats fed a high-salt diet, confirming severe apoptosis. This study suggests that the increase in endothelial cell apoptosis in TA muscle might contribute to the attenuation of angiogenesis response observed in rats fed a high-salt diet.

Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake. Publishing Authors By Initials

MM de Resende,SL Amaral,DH Munzenmaier,AS Greene,

For similar peptides: intracellular signaling peptides and proteins: apoptosis regulatory proteins: proto-oncogene proteins c-bcl-2: bcl-2-associated x protein research abstracts see: peptides: intracellular signaling peptides and proteins: apoptosis regulatory proteins: proto-oncogene proteins c-bcl-2: bcl-2-associated x protein research

PUBMED ID PMID:

MEDLINE DATE:

Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Physiological genomics

VOLUME: 25

Page Numbers: 325-35

Journal Abbreviation: Physiol. Genomics

ISSN: 1531-2267

DAY: 7

MONTH: 02

YEAR: 2006

Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9815683

Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake. Keywords Mesh Terms:

KEYWORDS: bcl-2-Associated X Protein

MESH TERMS: metabolism

Chemical & Substance for Abstract: Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake.

AFFILIATION: Biotechnology and Bioengineering Center, Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: N01-HV-28182

ACRONYM: HV

MEDLINETA: Physiol Genomics

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake Related Publications

• A DNA-translocating Snf2 molecular motor: Saccharomyces cerevisiae Rdh54 displays processive translocation and extrudes DNA loops.
• A functional magnetic resonance imaging investigation of short-term source and item memory for negative pictures.
• A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report.
• APOBEC3G and HIV-1:Strike and Counterstrike.
• Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle.
• Biochemistry and therapeutic implications of mechanisms involved in FOXP3 activity in immune suppression.
• Bridging cultural chasms between providers and HIV-positive Haitians in Palm Beach County, Florida.
• Combined effects of low-dose spironolactone and captopril therapy in a rat model of genetic hypertrophic cardiomyopathy.
• Dirty superconductivity in the electron-doped cuprate Pr(2-x)Ce(x)CuO(4-delta): tunneling study.
• Editorial comment on: systematic assessment of the ability of the number and percentage of positive biopsy cores to predict pathologic stage and biochemical recurrence after radical prostatectomy.
• ErbB receptors: from oncogenes to targeted cancer therapies.
• FOXP3 actively represses transcription by recruiting the HAT/HDAC complex.
• Factors associated with medication hassles experienced by family caregivers of older adults.
• Gender-specific design in total knee arthroplasty.
• High-field Hall resistivity and magnetoresistance of electron-doped Pr2-xCexCuO4-delta.
• In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions.
• Isolation of signal transduction complexes using biotin and crosslinking methodologies.
• Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease.
• Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.
• PET positive generalized lymphadenopathy and splenomegaly following interferon-alfa-2b adjuvant therapy for melanoma.
• Partial suppression of CETP activity beneficially modifies the lipid transfer profile of plasma.
• Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model.
• Rapid determination of double-bond positions in monoenoic fatty acids by periodate-permanganate oxidation.
• Regulation of HIV-1 latency by T-cell activation.
• Relative quantification of peptide phosphorylation in a complex mixture using 18O labeling.
• Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake.
• Spectrum and dynamics of the BCS-BEC crossover from a few-body perspective.
• Structural plasticity in the oestrogen receptor ligand-binding domain.
• The personal health record: a key to improving health care for seniors.
• Who runs? A demographic profile of runaway youth in the United States.