[Role of endogenous hydrogen sulfide in pulmonary hypertension induced by lipopolysaccharide.]

[Role of endogenous hydrogen sulfide in pulmonary hypertension induced by lipopolysaccharide.] Research Abstract Details 

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[Role of endogenous hydrogen sulfide in pulmonary hypertension induced by lipopolysaccharide.] Abstract Text:

The purpose of the present study was to explore the role of endogenous hydrogen sulfide (H2S) in pulmonary arterial hypertension induced by endotoxin. Adult male Sprague-Dawley (SD) rats were randomly divided into four groups: Control group (0.5 mL/kg body weight of normal saline, i.v.), lipopolysaccharide (LPS)-treated group (5 mg/kg body weight of LPS, i.v.), LPS + NaHS (5 mg/kg body weight of LPS, i.v., and 28 mumol/kg body weight of NaHS, i.p.) and LPS + PPG group (5 mg/kg body weight of LPS, i.v., and 30 mumol/kg body weight of PPG, i.p.). Rats were anesthetized with 20% urethane (1 g/kg body weight, i.p.). A polyethylene catheter was inserted into the pulmonary artery through the right external jugular vein to measure the mean pulmonary arterial pressure (mPAP) for 7 h, and then the pulmonary artery was isolated rapidly by the method described previously. Pulmonary arterial activity was detected. H2S concentration and cystathionine gamma-lyase (CSE) activity in pulmonary artery tissues were determined by biochemical method. CSE mRNA expression was detected by competitive reverse transcriptase-polymerase chain reaction (RT-PCR). Compared with control, LPS significantly increased mPAP [(1.82+/-0.29) kPa vs (1.43+/-0.26) kPa, P<0.01], decreased H2S production [(26.33+/-7.84) vs (42.92+/-8.73) pmol/g wet tissue per minute, P<0.01), and reduced endothelium-dependent relaxation response [(75.72+/-7.22)% vs (86.40+/-4.40) %, P<0.01) induced by ACh (1x10(-6) mol/L). These effects were partly reversed by co-administration of NaHS and enhanced by co-administration of PPG. Both CSE activity and CSE mRNA expression were consistent with H2S production. It is suggested that the inhibitory effect of LPS on endothelium-dependent relaxation results in pulmonary hypertension, which might be mediated through H2S.

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[Role of endogenous hydrogen sulfide in pulmonary hypertension induced by lipopolysaccharide.] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Sheng li xue bao : [Acta physiologica Sinica]

VOLUME: 60

Page Numbers: 211-5

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ISSN: 0371-0874

DAY: 25

MONTH: Apr

YEAR: 2008

[Role of endogenous hydrogen sulfide in pulmonary hypertension induced by lipopolysaccharide.] Information

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LANGUAGE: chi

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Grant and Affiliation Information for [Role of endogenous hydrogen sulfide in pulmonary hypertension induced by lipopolysaccharide.]

AFFILIATION: Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China. E-mail: huangxinli2006@hotmail.com.

Country: China

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MEDLINETA: Sheng Li Xue Bao

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