Role of cyclic mPer2 expression in the mammalian cellular clock.

Role of cyclic mPer2 expression in the mammalian cellular clock. Research Abstract Details 

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Role of cyclic mPer2 expression in the mammalian cellular clock. Abstract Text:

Yoshinobu Yamamoto,Kazuhiro Yagita,Hitoshi Okamura,

To explore the role of mPer2 in the circadian oscillation in the mammalian cellular clock, we established fibroblast cell lines in which expression of mPer2 is controlled through a tetracycline-regulatable promoter. We revealed that constitutive expression and overexpression of mPer2 mRNA severely impair serum shock-induced cyclic circadian clock gene expression. Moreover, under conditions of lower mPer2 mRNA expression, mPER2 protein accumulation in these cells showed clear circadian oscillation even in constitutive mPer2 mRNA expression, suggesting that the protein cycling of mPER2 was required for oscillation of the circadian feedback loop. Since the rhythms of gene expression driven by the intrinsic clock oscillation system dampen rapidly in the absence of cyclic expression of mPer2, the transcriptional rhythm helps to sustain the clock oscillation.

Role of cyclic mPer2 expression in the mammalian cellular clock. Publishing Authors By Initials

Y Yamamoto,K Yagita,H Okamura,

For similar proteins: ubiquitins: ubiquitin research abstracts see: proteins: ubiquitins: ubiquitin research

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Role of cyclic mPer2 expression in the mammalian cellular clock. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular biology

VOLUME: 25

Page Numbers: 1912-21

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 0270-7306

DAY: 19

MONTH: Mar

YEAR: 2005

Role of cyclic mPer2 expression in the mammalian cellular clock. Information

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LANGUAGE: eng

NlmUniqueID: 8109087

Role of cyclic mPer2 expression in the mammalian cellular clock. Keywords Mesh Terms:

KEYWORDS: Ubiquitin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Role of cyclic mPer2 expression in the mammalian cellular clock. Information

Substance Name: Proteasome Endopeptidase Complex

Registry Number: EC 3.4.25.1

Grant and Affiliation Information for Role of cyclic mPer2 expression in the mammalian cellular clock.

AFFILIATION: Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

Country: United States

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MEDLINETA: Mol Cell Biol

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