Role of central serotonergic (5-HT2) receptor in blood pressure regulation in rats.

Role of central serotonergic (5-HT2) receptor in blood pressure regulation in rats. Research Abstract Details 

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Role of central serotonergic (5-HT2) receptor in blood pressure regulation in rats. Abstract Text:

T Kushiro,H Kurumatani,T Ishii,H Yokoyama,J Koike,Y Hatayama,Y Kobayashi,N Kajiwara,

To investigate the role of the serotonergic nervous system in blood pressure regulation, 5 micrograms of 5-hydroxytryptamine (5-HT) was given i.c.v. before and after 1 microgram of i.c.v. xylamidine or 200 micrograms of i.c.v. ketanserin or 200 micrograms of i.v. ketanserin in conscious Wistar Kyoto rats. Also i.v. (0.5, 1, 2 micrograms) or i.c.v. (1 microgram) phenylephrine (PHE) were given before and after 1 microgram of i.c.v. xylamidine. I.c.v. 5-HT elicited a consistent pressor response of approximately 27mmHg and slight decrease in heart rate. MAP and heart rate did not change after xylamidine or ketanserin. Whereas pressor response to i.c.v. 5-HT after i.c.v. ketanserin or i.c.v. xylamidine was suppressed, it did not change after i.v. ketanserin. Neither i.c.v. nor i.v. PHE-induced pressor response was influenced by i.c.v. xylamidine pretreatment. These data suggest that the central 5-HT2 receptor may subserve pressor function in rats.

Role of central serotonergic (5-HT2) receptor in blood pressure regulation in rats. Publishing Authors By Initials

T Kushiro,H Kurumatani,T Ishii,H Yokoyama,J Koike,Y Hatayama,Y Kobayashi,N Kajiwara,

For similar proteins: membrane proteins: receptors, cell surface: receptors, biogenic amine: receptors, serotonin research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, biogenic amine: receptors, serotonin research

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Role of central serotonergic (5-HT2) receptor in blood pressure regulation in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 10 Suppl 1

Page Numbers: 339-45

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1988

Role of central serotonergic (5-HT2) receptor in blood pressure regulation in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Role of central serotonergic (5-HT2) receptor in blood pressure regulation in rats. Keywords Mesh Terms:

KEYWORDS: Receptors, Serotonin

MESH TERMS: physiology

Chemical & Substance for Abstract: Role of central serotonergic (5-HT2) receptor in blood pressure regulation in rats. Information

Substance Name: Ketanserin

Registry Number: 74050-98-9

Grant and Affiliation Information for Role of central serotonergic (5-HT2) receptor in blood pressure regulation in rats.

AFFILIATION: Dept. of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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