Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe.

Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe. Research Abstract Details 

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Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe. Abstract Text:

C W Nakagawa,K Yamada,N Mutoh,

We examined the induction of the catalase gene (ctt1(+)) of fission yeast Schizosaccharomyces pombe in response to several stresses by using mutants of transcription factors (Atf1 and Pap1) and a series of deletion mutants of the ctt1(+) promoter region. A transcription factor, Atf1, and its binding site are necessary for the induction of ctt1(+) by osmotic stress, UV irradiation, and heat shock. Induction by menadione treatment, which produces superoxide anion, required element A, the region from -111 to -90 (numbered with the transcription start site as +1). The factor responsible for the induction of the gene by oxidative stress via element A was identified as the transcription factor Pap1. We also found that Atf1 is activated by menadione treatment in pap1 mutant cells, although it is not activated by menadione treatment in pap1(+) cells. The activity of catalase is not increased in pap1 cells by several stresses, despite mRNA induction, suggesting that Pap1 plays some role in the expression of catalase activity.

Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe. Publishing Authors By Initials

CW Nakagawa,K Yamada,N Mutoh,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 127

Page Numbers: 233-8

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Feb

YEAR: 2000

Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe. Information

Substance Name: Acetyltransferases

Registry Number: EC 2.3.1.-

Grant and Affiliation Information for Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe.

AFFILIATION: Department of Genetics, Institute for Developmental Research, Kagiya-cho, Kasugai, Aichi 480-0392, Japan. normutoh@inst-hsc.pref. aichi.jp

Country: JAPAN

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MEDLINETA: J Biochem

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