Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt.

Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Abstract Text:

Marlon P Quinones,Yogeshwar Kalkonde,Carlos A Estrada,Fabio Jimenez,Robert Ramirez,Lenin Mahimainathan,Srinivas Mummidi,Goutam G Choudhury,Hernan Martinez,Lisa Adams,Matthias Mack,Robert L Reddick,Shivani Maffi,Sylva Haralambous,Lesley Probert,Sunil K Ahuja,Seema S Ahuja,Marlon P Quinones,Yogeshwar Kalkonde,Carlos A Estrada,Fabio Jimenez,Robert Ramirez,Lenin Mahimainathan,Srinivas Mummidi,Goutam G Choudhury,Hernan Martinez,Lisa Adams,Matthias Mack,Robert L Reddick,Shivani Maffi,Sylva Haralambous,Lesley Probert,Sunil K Ahuja,Seema S Ahuja,Marlon P Quinones,Yogeshwar Kalkonde,Carlos A Estrada,Fabio Jimenez,Robert Ramirez,Lenin Mahimainathan,Srinivas Mummidi,Goutam G Choudhury,Hernan Martinez,Lisa Adams,Matthias Mack,Robert L Reddick,Shivani Maffi,Sylva Haralambous,Lesley Probert,Sunil K Ahuja,Seema S Ahuja,

Chemotactic factors known as chemokines play an important role in the pathogenesis of multiple sclerosis (MS). Transgenic expression of TNFalpha in the central nervous system (CNS) leads to the development of a demyelinating phenotype (TNFalpha-induced demyelination; TID) that is highly reminiscent of MS. Little is known about the role of chemokines in TID but insights derived from studying this model might extend our current understanding of MS pathogenesis and complement data derived from the classic autoimmune encephalomyelitis (EAE) model system. Here we show that in TID, chemokines and their receptors were significantly increased during the acute phases of disease. Notably, the CCL2 (MCP-1)-CCR2 axis and the closely related ligand-receptor pair CCR1-CCL3 (MIP-1alpha) were among the most up-regulated during disease. On the other hand, receptors like CCR3 and CCR4 were not elevated. This significant increase in the levels of chemokines/receptors correlated with robust immune infiltration of the CNS by inflammatory cells, i.e., macrophages, and immune cells particularly T and B cells. Immunostaining and confocal microscopy, along with in vitro studies revealed that astrocytes were a major source of locally produced chemokines and expressed functional chemokine receptors such as CCR2. Using an in vitro system we demonstrate that expression of CCR2 was functional in astrocytes and that signaling via this receptor lead to activation of NF-kB and Akt and was associated with increased astrocyte survival. Collectively, our data suggests that transgenic murine models of MS are useful to dissect mechanisms of disease and that in these models, up-regulation of chemokines and their receptors may be key determinants in TID.

Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Publishing Authors By Initials

MP Quinones,Y Kalkonde,CA Estrada,F Jimenez,R Ramirez,L Mahimainathan,S Mummidi,GG Choudhury,H Martinez,L Adams,M Mack,RL Reddick,S Maffi,S Haralambous,L Probert,SK Ahuja,SS Ahuja,MP Quinones,Y Kalkonde,CA Estrada,F Jimenez,R Ramirez,L Mahimainathan,S Mummidi,GG Choudhury,H Martinez,L Adams,M Mack,RL Reddick,S Maffi,S Haralambous,L Probert,SK Ahuja,SS Ahuja,MP Quinones,Y Kalkonde,CA Estrada,F Jimenez,R Ramirez,L Mahimainathan,S Mummidi,GG Choudhury,H Martinez,L Adams,M Mack,RL Reddick,S Maffi,S Haralambous,L Probert,SK Ahuja,SS Ahuja,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular and cellular neurosciences

VOLUME: 37

Page Numbers: 96-109

Journal Abbreviation: Mol. Cell. Neurosci.

ISSN: 1044-7431

DAY: 14

MONTH: 09

YEAR: 2007

Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9100095

Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt.

AFFILIATION: South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, TX, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mol Cell Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt Related Publications

• A rare congenital anastomosis between the vertebral artery and internal carotid artery.
• A topological and temporal correlator network for spatiotemporal pattern learning, recognition, and recall.
• An analytically tractable potential field model of free space and its application in obstacle avoidance.
• Biopsy of deep-seated head and neck lesions under intraoral ultrasound guidance.
• CC chemokine receptor 5 influences late-stage atherosclerosis.
• Chest radiograph scores as potential prognostic indicators in severe acute respiratory syndrome (SARS).
• Clinical experience with sulphonylureas.
• Effects of allo-immunization of goat bucks with goat-testes homogenates on spermatogenesis sperm motility and production of cross reacting antibodies.
• Electron transport in stretched monoatomic gold wires.
• Eye of the storm: the roles of a radiology department in the outbreak of severe acute respiratory syndrome.
• Fever of unknown origin: is there a role for empiric therapy?
• First-time shoulder dislocation: High prevalence of labral injury and age-related differences revealed by MR arthrography.
• Formation of sp3 hybridized bonds and stability of CaCO3 at very high pressure.
• Hemangioendothelioma of the parotid gland in infants: sonography and correlative MR imaging.
• High-resolution sonography of the submandibular space: anatomy and abnormalities.
• Imaging of severe acute respiratory syndrome in Hong Kong.
• Li-decorated metal-organic framework 5: a route to achieving a suitable hydrogen storage medium.
• Lossless image compression with multiscale segmentation.
• Normal variation in the density of selected human bones in North India. A necropsy study.
• Observations on a spontaneous case of fatal ovine mastitis due to Klebsiella pneumoniae.
• Parallel distributed detection of feature trajectories in multiple discontinuous motion image sequences.
• Prevalence of Duodenal Ulcer-Promoting Gene (dupA) of Helicobacter pylori in Patients with Duodenal Ulcer in North Indian Population.
• Production of specific mRNA transcripts, usage of an alternate promoter, and octamer-binding transcription factors influence the surface expression levels of the HIV coreceptor CCR5 on primary T cells.
• Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt.
• SARS and the modern day pony express (the World Wide Web).
• Severe acute respiratory syndrome: avoiding the spread of infection in a radiology department.
• Synthesis of intergeneric hybrids and establishment of genomic affinity between Diplotaxis catholica and crop Brassica species.
• Towards generating caffeine-free tea by metabolic engineering.
• [Not Available.]
• [Not Available.]