Role of amino acids in cochlear degeneration: morphological changes in cochlear outer hair cells following glutamate application.

Role of amino acids in cochlear degeneration: morphological changes in cochlear outer hair cells following glutamate application. Research Abstract Details 

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Role of amino acids in cochlear degeneration: morphological changes in cochlear outer hair cells following glutamate application. Abstract Text:

K Sunami,H Yamane,K Konishi,H Iguchi,T Nakagawa,S Shibata,M Takayama,Y Nakai,

Glutamate is an excitatory neurotransmitter in the cochlea and has toxic effects on the organ of Corti in various pathological conditions. The toxic effects of glutamate have not been determined in detail. In this study, we examined morphological changes in the organ of Corti of guinea pigs following local application of glutamate. Morphological changes were noted in outer hair cells. Degeneration of outer hair cells was found 24 h after glutamate treatment. The extent of degeneration depended on exposure time. Inner hair cells did not exhibit any degeneration. In addition, no degenerative changes were detected in nerve endings attached to hair cells. These findings suggest that outer hair cells are the initial site of degeneration caused by application of excess glutamate to the inner ear.

Role of amino acids in cochlear degeneration: morphological changes in cochlear outer hair cells following glutamate application. Publishing Authors By Initials

K Sunami,H Yamane,K Konishi,H Iguchi,T Nakagawa,S Shibata,M Takayama,Y Nakai,

For similar ear, inner: cochlea: organ of corti research abstracts see: ear, inner: cochlea: organ of corti research

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Role of amino acids in cochlear degeneration: morphological changes in cochlear outer hair cells following glutamate application. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta oto-laryngologica. Supplementum

VOLUME: 538

Page Numbers: 22-5

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: 02

YEAR: 1998

Role of amino acids in cochlear degeneration: morphological changes in cochlear outer hair cells following glutamate application. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Role of amino acids in cochlear degeneration: morphological changes in cochlear outer hair cells following glutamate application. Keywords Mesh Terms:

KEYWORDS: Organ of Corti

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Role of amino acids in cochlear degeneration: morphological changes in cochlear outer hair cells following glutamate application. Information

Substance Name: Glutamic Acid

Registry Number: 56-86-0

Grant and Affiliation Information for Role of amino acids in cochlear degeneration: morphological changes in cochlear outer hair cells following glutamate application.

AFFILIATION: Department of Otorhinolaryngology, Osaka City University Medical School, Japan.

Country: NORWAY

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MEDLINETA: Acta Otolaryngol Suppl

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