Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle.

Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle. Research Abstract Details 

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Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle. Abstract Text:

Yan Lin,Soledad Cabeza de Vaca,Kenneth D Carr,Eric A Stone,

The present experiments were undertaken to clarify the role of central alpha(1)-adrenoceptors in reward processes. Rats, trained to self-stimulate via electrodes in the medial forebrain bundle of the lateral hypothalamus, were administered alpha(1)-selective drugs near the locus coeruleus (LC), a site of a dense concentration of alpha(1)-receptors. Effects on reward potency were assessed from shifts in rate-frequency curves while effects on motor response capacity were judged from changes in the maximal rates of responding. It was found that local blockade of LC alpha(1)-receptors with terazosin produced a significant dose-dependent and site-dependent rightward shift of 0.08 log units and a significant decrease of 16.3% in the maximum response rate. Both effects were completely reversed by coadministration of the alpha(1)-agonist, phenylephrine and were not attributable to terazosin's weak action at alpha(2)-adrenoceptors. It is concluded that LC alpha(1)-adrenoceptors are involved both in reward/motivational processes and operant response elaboration which are postulated to work together to facilitate goal attainment.

Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle. Publishing Authors By Initials

Y Lin,SC de Vaca,KD Carr,EA Stone,

For similar therapeutics: drug therapy: self administration research abstracts see: therapeutics: drug therapy: self administration research

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Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuropsychopharmacology : official publication of

VOLUME: 32

Page Numbers: 835-41

Journal Abbreviation: Neuropsychopharmacology

ISSN: 0893-133X

DAY: 5

MONTH: 07

YEAR: 2006

Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8904907

Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle. Keywords Mesh Terms:

KEYWORDS: Self Administration

MESH TERMS: methods

Chemical & Substance for Abstract: Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle. Information

Substance Name: terazosine

Registry Number: 63590-64-7

Grant and Affiliation Information for Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle.

AFFILIATION: Department of Psychiatry, New York University School of Medicine, New York University Medical Center, New York, NY 10016, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH45265

ACRONYM: MH

MEDLINETA: Neuropsychopharmacology

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