Role of alpha-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity.

Role of alpha-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity. Research Abstract Details 

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Role of alpha-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity. Abstract Text:

Mayumi Watanabe,Chikako Tomiyama-Miyaji,Eisuke Kainuma,Masashi Inoue,Yuh Kuwano,Hongwei Ren,Jiwei Shen,Toru Abo,Mayumi Watanabe,Chikako Tomiyama-Miyaji,Eisuke Kainuma,Masashi Inoue,Yuh Kuwano,Hongwei Ren,Jiwei Shen,Toru Abo,

Mice were exposed to restraint stress for 3h. During this period, low body temperature (hypothermia, 39 degrees C-->less than 37 degrees C) and high blood glucose levels (hyperglycemia, 150mg/dl-->up to 220mg/dl) were simultaneously induced. Reflecting a stress-induced phenomenon, blood levels of catecholamines increased at that time. Administration of adrenaline (alpha-stimulus), but neither noradrenaline (alpha but less than adrenaline) nor isoproterenol (beta), induced a similar stress-induced pattern of body temperature and blood glucose variations. This alpha-adrenergic effect was confirmed using alpha- and beta-blockers in adrenaline-induced hypothermia and hyperglycemia. By applying this alpha-stimulus, the effect on immunoparameters was then investigated. Stress-resistant lymphocyte populations were found to be NK cells, extrathymic T cells and NKT cells, especially in the liver. Functional assays showed that both NK-cell cytotoxicity and NKT-cell cytotoxicity were augmented by alpha-stimulus. These results suggest that alpha-stimulus is one of the important factors in the stress-induced phenomenon and that it eventually produces hypothermia, hyperglycemia and innate-immunity activation seen during stress.

Role of alpha-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity. Publishing Authors By Initials

M Watanabe,C Tomiyama-Miyaji,E Kainuma,M Inoue,Y Kuwano,H Ren,J Shen,T Abo,M Watanabe,C Tomiyama-Miyaji,E Kainuma,M Inoue,Y Kuwano,H Ren,J Shen,T Abo,

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Role of alpha-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Immunology letters

VOLUME: 115

Page Numbers: 43-9

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ISSN: 0165-2478

DAY: 23

MONTH: 10

YEAR: 2007

Role of alpha-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity. Information

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LANGUAGE: eng

NlmUniqueID: 7910006

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Grant and Affiliation Information for Role of alpha-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity.

AFFILIATION: Department of Immunology, Niigata University School of Medicine, Niigata 951-8510, Japan.

Country: Netherlands

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MEDLINETA: Immunol Lett

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