Role of aldose reductase in the peritoneal changes of patients undergoing peritoneal dialysis.

Role of aldose reductase in the peritoneal changes of patients undergoing peritoneal dialysis. Research Abstract Details 

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Role of aldose reductase in the peritoneal changes of patients undergoing peritoneal dialysis. Abstract Text:

Yukiko Hasuike,Rintarou Moriguchi,Reiko Hata,Kouji Miyagawa,Takahiro Kuragano,Masayo Aizawa,Shigeo Yamamoto,Kimihiko Yanase,Masaaki Izumi,Tsuyoshi Tanimoto,Takeshi Nakanishi,Yukiko Hasuike,Rintarou Moriguchi,Reiko Hata,Kouji Miyagawa,Takahiro Kuragano,Masayo Aizawa,Shigeo Yamamoto,Kimihiko Yanase,Masaaki Izumi,Tsuyoshi Tanimoto,Takeshi Nakanishi,

BACKGROUND/AIMS: The mesothelium of patients undergoing peritoneal dialysis (PD) is exposed to glucose in dialysate. Glucose metabolites 3-deoxyglucosone and advanced glycation endproducts (AGEs) in the PD fluid induce peritoneal damage. Circulating factors also affect the peritoneum in the uremic model and predialysis patients. Aldose reductase (AR) generates precursors of 3-deoxyglucosone. We have reported AR acceleration in uremic patients. Therefore, AR acceleration might affect the peritoneum. The purpose of this study was to evaluate the AR level in PD patients and to determine the factors that change the peritoneum of these patients. METHODS: We measured the PD effluent (eff-) concentration of cancer antigen 125 (CA125) as a marker of mesothelial viability in PD patients. Erythrocyte AR, eff-, and plasma (p-) concentrations of 3-deoxyglucosone, AGEs, and malondialdehyde were also studied in 30 PD patients, 18 patients undergoing hemodialysis, and 8 control subjects. RESULTS: In the PD group, AR, p-3-deoxyglucosone, p-AGEs, and p-malondialdehyde were higher than in the control group. The predictors for eff-CA125 were not only PD duration and eff-3-deoxyglucosone, but also AR. CONCLUSION: AR was upregulated in PD patients. AR acceleration may affect the peritoneum in these patients. Further studies are needed to clarify the role of AR in PD patients.

Role of aldose reductase in the peritoneal changes of patients undergoing peritoneal dialysis. Publishing Authors By Initials

Y Hasuike,R Moriguchi,R Hata,K Miyagawa,T Kuragano,M Aizawa,S Yamamoto,K Yanase,M Izumi,T Tanimoto,T Nakanishi,Y Hasuike,R Moriguchi,R Hata,K Miyagawa,T Kuragano,M Aizawa,S Yamamoto,K Yanase,M Izumi,T Tanimoto,T Nakanishi,

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Role of aldose reductase in the peritoneal changes of patients undergoing peritoneal dialysis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of nephrology

VOLUME: 27

Page Numbers: 622-9

Journal Abbreviation: Am. J. Nephrol.

ISSN: 1421-9670

DAY: 11

MONTH: 09

YEAR: 2007

Role of aldose reductase in the peritoneal changes of patients undergoing peritoneal dialysis. Information

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LANGUAGE: eng

NlmUniqueID: 8109361

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Grant and Affiliation Information for Role of aldose reductase in the peritoneal changes of patients undergoing peritoneal dialysis.

AFFILIATION: Department of Nephrology and Dialysis, Hyogo College of Medicine, Hyogo, Japan. cherry39@hyo-med.ac.jp

Country: Switzerland

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MEDLINETA: Am J Nephrol

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