Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications.

Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications. Abstract Text:

Matthias Lange,Andrea Morelli,Christian Ertmer,Katrin ,Sebastian Rehberg,Hugo Van Aken,Daniel L Traber,Martin Westphal,Matthias Lange,Andrea Morelli,Christian Ertmer,Katrin ,Sebastian Rehberg,Hugo Van Aken,Daniel L Traber,Martin Westphal,

Shock states are associated with an impaired tissue oxygen supply-demand relationship and perturbations within the microcirculation, leading to global tissue hypoxia, finally resulting in multiple-organ failure or even death. Two of the most frequent causes of shock are acute hemorrhage and sepsis. Although the origin and the pathophysiology of hemorrhagic and septic shock are basically different, the involvement of adenosine triphosphate-sensitive potassium (KATP) channels, as an important regulator of vascular smooth muscles tone, plays a pivotal role under both conditions. Because the excessive activation of vascular KATP channels is a major cause of arterial hypotension and vascular hyporesponsiveness to catecholamines, the pharmacological inhibition of KATP channels may represent a goal-directed therapeutic option to stabilize the hemodynamic situation in shock states. Despite promising results of preclinical studies, the efficacy of this innovative therapeutic approach remains to be confirmed in the clinical setting. The differences in the species, the comorbidity, and the difficulty in determining the exact onset of shock in clinical practice and, thus, any duration-related alterations in vascular responses and KATP channel activation may explain the discrepancy between the results obtained from experimental and clinical studies. Currently, two of the most relevant problems related to effective KATP blockade in shock states are represented by (1) the dose itself (benefit-risk ratio) and (2) the route of administration (oral vs. i.v.). This review article critically elucidates the published in vivo studies on the role of KATP channel inhibition in both described shock forms and discusses the advantages and the potential pitfalls related to the treatment of human shock states.

Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications. Publishing Authors By Initials

M Lange,A Morelli,C Ertmer,K ,S Rehberg,H Van Aken,DL Traber,M Westphal,M Lange,A Morelli,C Ertmer,K ,S Rehberg,H Van Aken,DL Traber,M Westphal,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications. Journal Published:

PUBLICATION TYPE: Review

Journal: Shock (Augusta, Ga.)

VOLUME: 28

Page Numbers: 394-400

Journal Abbreviation: Shock

ISSN: 1073-2322

DAY: 12

MONTH: Oct

YEAR: 2007

Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications. Information

Number of References: 58

LANGUAGE: eng

NlmUniqueID: 9421564

Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications.

AFFILIATION: Department of Anesthesiology and Intensive Care, University of Muenster, Germany. lange-m@anit.uni-muenster.de

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Shock

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications Related Publications

• Amebiasis with pulmonary involvement.
• Continuous terlipressin infusion in patients with septic shock: less may be best, and the earlier the better?
• Cyclooxygenase-2 inhibition and increased arterial vasoconstriction to vasopressin: What is the link?
• Epidemiology of Epidemic Keratoconjunctivitis.
• Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia.
• Experiences of Somatonorm in Sweden.
• Fleet leaders' attitudes about subordinates' use of mental health services.
• Hemodynamic effects of thoracic epidural analgesia in ovine hyperdynamic endotoxemia.
• Hollow mandrin facilitates external ventricular drainage placement.
• Is short stature a psychosocial handicap?
• LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum.
• Living at risk: concealing risk and preserving hope in huntington disease.
• New frontiers in health education.
• Optimal perfusion of an intact ovary as a prerequisite for successful ovarian cryopreservation.
• Preparation and characteristics of corticosteroid-binding globulin (CBG, transcortin).
• Pulmonary resection for metastatic sarcoma.
• Purification of Coxiella burnetii antigen by gel-chromatography for use in enzyme-linked immunosorbent assay (ELISA).
• Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications.
• Sensors, medical image and signal processing. Findings from the section on sensor, signal and imaging informatics.
• Ten years of vasopressin research in septic shock: constant dripping wears the stone.
• The Problem of the Gonococcus Carrier.
• [Immunochemistry of O-antigens of Enterobacteriaceae. IV. Analysis of the sugar constituents of Escherichia O-antigens.]
• [Methods for analysis of amniotic fluid for diagnosis of the fetal condition in Rh-incompatibility]
• [Not Available.]
• [Not Available.]
• [On the immunochemistry of the O-antigen of Enterobacteriaceae. VI. Comparison of the sugar components of polysaccharides from S and R forms of Salmonella.]
• [Perinatal and neonatal mortality and morbidity in newborn infants up to 1,000 g]
• [Reliability and responsiveness of the German version of the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH).]
• [Salivary secretion and gingival hyperplasia in diphenyl hydantoin-treated guinea pigs]
• [Specificity of calcium determination using tetracycline]