Role of acetylcholine in neurotransmission of the carotid body.

Role of acetylcholine in neurotransmission of the carotid body. Research Abstract Details 

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Role of acetylcholine in neurotransmission of the carotid body. Abstract Text:

Machiko Shirahata,Alexander Balbir,Toshiki Otsubo,Robert S Fitzgerald,

Acetylcholine (ACh) has been considered an important excitatory neurotransmitter in the carotid body (CB). Its physiological and pharmacological effects, metabolism, release, and receptors have been well documented in several species. Various nicotinic and muscarinic ACh receptors are present in both afferent nerve endings and glomus cells. Therefore, ACh can depolarize or hyperpolarize the cell membrane depending on the available receptor type in the vicinity. Binding of ACh to its receptor can create a wide variety of cellular responses including opening cation channels (nicotinic ACh receptor activation), releasing Ca(2+) from intracellular storage sites (via muscarinic ACh receptors), and modulating activities of K(+) and Ca(2+) channels. Interactions between ACh and other neurotransmitters (dopamine, adenosine, nitric oxide) have been known, and they may induce complicated responses. Cholinergic biology in the CB differs among species and even within the same species due to different genetic composition. Development and environment influence cholinergic biology. We discuss these issues in light of current knowledge of neuroscience.

Role of acetylcholine in neurotransmission of the carotid body. Publishing Authors By Initials

M Shirahata,A Balbir,T Otsubo,RS Fitzgerald,

For similar biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research

PUBMED ID PMID:

MEDLINE DATE:

Role of acetylcholine in neurotransmission of the carotid body. Journal Published:

PUBLICATION TYPE: Review

Journal: Respiratory physiology & neurobiology

VOLUME: 157

Page Numbers: 93-105

Journal Abbreviation:

ISSN: 1569-9048

DAY: 11

MONTH: 01

YEAR: 2007

Role of acetylcholine in neurotransmission of the carotid body. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101140022

Role of acetylcholine in neurotransmission of the carotid body. Keywords Mesh Terms:

KEYWORDS: Species Specificity

MESH TERMS: metabolism

Chemical & Substance for Abstract: Role of acetylcholine in neurotransmission of the carotid body. Information

Substance Name: Acetylcholine

Registry Number: 51-84-3

Grant and Affiliation Information for Role of acetylcholine in neurotransmission of the carotid body.

AFFILIATION: Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA. mshiraha@jhsph.edu

Country: Netherlands

AGENCY: United States NHLBI

GRANT: T32 HL07534

ACRONYM: HL

MEDLINETA: Respir Physiol Neurobiol

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