Role of 99mTc-octreotide acetate scintigraphy in suspected lung cancer compared with 18F-FDG dual-head coincidence imaging.

Role of 99mTc-octreotide acetate scintigraphy in suspected lung cancer compared with 18F-FDG dual-head coincidence imaging. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Role of 99mTc-octreotide acetate scintigraphy in suspected lung cancer compared with 18F-FDG dual-head coincidence imaging. Abstract Text:

Feng Wang,Zizheng Wang,Weixuan Yao,Hong Xie,Jie Xu,Li Tian,

The aim of this study was to evaluate the clinical value of tomographic (99m)Tc-octreotide acetate (hereafter, (99m)Tc-octreotide) scintigraphy in the detection of patients with suspected lung cancer in comparison with that of (18)F-FDG dual-head coincidence imaging (DHC). METHODS: Forty-four consecutive patients with suspected pulmonary neoplasms underwent tomographic (99m)Tc-octreotide scintigraphy and (18)F-FDG coincidence imaging using the same gantry. The region of interest was drawn on the entire primary lesion. The tumor-to-normal tissue tracer values for both (99m)Tc-octreotide and (18)F-FDG were determined using region of interests and expressed as T/N(r) and T/N(m), respectively. Final diagnosis was confirmed by histopathologic analysis or clinical follow-up. RESULTS: Thirty-one of the 44 patients had lung cancer-6 with small cell lung cancer (SCLC) and 25 with non-small cell lung cancer (NSCLC). Thirteen of the 44 patients had benign lung lesions. The sensitivity, specificity, positive predictive value, and negative predictive value of (99m)Tc-octreotide were 100%, 75.7%, 90.1%, and 100%, respectively, and of (18)F-FDG DHC were 100%, 46.1%, 83.8%, and 100%, respectively. In the 31 patients with malignant tumors, all 38 abnormal lymph nodes in 20 patients showed abnormal high focal uptake of (18)F-FDG; only 7 patients with 10 regional lymph adenopathies showed moderate uptake of (99m)Tc-octreotide. Thirteen patients with 39 distant sites of abnormal uptake visualized (imaging stage IV) with (99m)Tc-octreotide included 2 patients with brain metastases, 6 patients with pleural invasion and multiple bone metastasis, 2 patients with contralateral internal lung metastasis and pleural invasion, and 3 patients with only multiple bone metastasis. The final diagnosis was confirmed by histopathology or clinical follow-up. CONCLUSION: The sensitivity of (99m)Tc-octreotide for the detection of lung cancer at the primary lesion was comparable with that of (18)F-FDG coincidence imaging. Tomographic (99m)Tc-octreotide scintigraphy had lower sensitivity for the detection of hilar and mediastinal lymph node metastasis compared with that of (18)F-FDG coincidence PET, but it had high sensitivity for the detection of remote metastatic lesions. However, because of the small population, further investigation is necessary.

Role of 99mTc-octreotide acetate scintigraphy in suspected lung cancer compared with 18F-FDG dual-head coincidence imaging. Publishing Authors By Initials

F Wang,Z Wang,W Yao,H Xie,J Xu,L Tian,

For similar chemical actions and uses: specialty uses of chemicals: laboratory chemicals: indicators and reagents: radiopharmaceuticals research abstracts see: chemical actions and uses: specialty uses of chemicals: laboratory chemicals: indicators and reagents: radiopharmaceuticals research

PUBMED ID PMID:

MEDLINE DATE:

Role of 99mTc-octreotide acetate scintigraphy in suspected lung cancer compared with 18F-FDG dual-head coincidence imaging. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of nuclear medicine : official publication

VOLUME: 48

Page Numbers: 1442-8

Journal Abbreviation: J. Nucl. Med.

ISSN: 0161-5505

DAY: 17

MONTH: 08

YEAR: 2007

Role of 99mTc-octreotide acetate scintigraphy in suspected lung cancer compared with 18F-FDG dual-head coincidence imaging. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217410

Role of 99mTc-octreotide acetate scintigraphy in suspected lung cancer compared with 18F-FDG dual-head coincidence imaging. Keywords Mesh Terms:

KEYWORDS: Radiopharmaceuticals

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Role of 99mTc-octreotide acetate scintigraphy in suspected lung cancer compared with 18F-FDG dual-head coincidence imaging. Information

Substance Name: Octreotide

Registry Number: 83150-76-9

Grant and Affiliation Information for Role of 99mTc-octreotide acetate scintigraphy in suspected lung cancer compared with 18F-FDG dual-head coincidence imaging.

AFFILIATION: Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 68 Chang-le Road, Nanjing 210006, China.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Nucl Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Role of 99mTc-octreotide acetate scintigraphy in suspected lung cancer compared with 18F-FDG dual-head coincidence imaging Related Publications

• [Adsorption studies of gamma-aminopropyltrimethoxysilane on iron surfaces by surface-enhanced Raman spectroscopy]
• [Advances in the study of fertilization mechanism of angiosperms]
• [Changes in endothelin-1 and calcitonin gene-related peptide in myocardium after severe burn and delayed fluid resuscitation in rats at different altitudes on plateau.]
• [Changes of erythrocyte membrane lipid in hereditary G6PD deficiency]
• [Comparison of serum biochemical features between SARS and other viral pneumonias]
• [Comparison of the Chinese LJ strain structural gene with HM175, MBB, LA strains and the expression of hepatitis A virus antigen by LJ/HM175 recombinant vaccinia virus]
• [Effect of alpha-melanocyte stimulating hormone on the apoptosis of the vascular endothelial cell of the lung in two-hit acute respiratory distress syndrome in rat]
• [Epidermal stem cells in the tympanic membrane]
• [Establishment of a coupling method of high performance liquid chromatography and capillary gas chromatography]
• [Establishment of a rabbit model of Acanthamoeba keratitis]
• [Glutathione S-transferase GSTM1 and GSTT1 genotypes and susceptibility to lung cancer]
• [Heterotopic osteogenesis of autogenous marrow stromal cells with recombinant human bone morphogenetic protein 2 gene transfection and porous calcium phosphate ceramic as a scaffold]
• [In situ raman spectroscopic study on the oxidation of HCHO on a roughened platinum electrode]
• [Measurements of diffusion reflectance and transmittance of biological tissues by using CCD]
• [Preliminary studies on proliferation of hemorrhagic fever with renal syndrome virus in Leptotrombidium (L.) Scutellare]
• [Progress in the study of gene duplication]
• [Radionuclide pulmonary perfusion imaging in evaluating pulmonary hypertension in patients with congenital heart disease]
• [Relationship between blood NO and PaO2 or PaCO2 levels of patients with acute carbon monoxide poisoning]
• [SERS mechanism for rhodium electrode in the ultraviolet region]
• [Significance of blood HCV RNA screening in the prevention of post-transfusion hepatitis C]
• [Speciation of aluminum in natural waters by fluorimetry]
• [Spontaneous healing of various types of rat tympanic membrane perforation]
• [Study of spectrometer calibration experiment research]
• [Study on the collagen constitution of hyperplastic scar in different ages and its influencing factors]
• [Surveillance of cerebral blood circulation changes by transcranial Doppler ultrasonography in patients with nasopharyngeal carcinoma after radiotherapy]
• [Synthesis, spectra, nonlinear optical properties and theoretical calculations of metal complexes containing phenothiazine ligand]
• [The cytochemical observation of anthers of Chinese cabbage's male-sterile]
• [The distribution of calcium in the stigma and style of tobacco during pollen germination and tube growth]
• [The significance of mutations in genomic evolution]
• [Value of carbon-11 choline positron emission tomography in patients with pulmonary abnormalities]