Role for plasmacytoid dendritic cells in anti-HIV innate immunity.

Role for plasmacytoid dendritic cells in anti-HIV innate immunity. Research Abstract Details 

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Role for plasmacytoid dendritic cells in anti-HIV innate immunity. Abstract Text:

Michaela ,Anne Hosmalin,Michaela ,Anne Hosmalin,

The role of plasmacytoid dendritic cells (pDC) in anti-HIV immunity is mostly represented by the production of type I IFN in response to HIV infection in vitro and in vivo. This production is decreased in HIV-1 infected patients at the time of primary infection and during chronic disease in association with progression of disease. Circulating pDC counts are decreased concomitantly with type I IFN, and both factors correlate inversely overall with viral loads and positively with CD4+ T-cell counts. These parameters might be used in clinical immunology to monitor treatment and as predictive factors of immune control of HIV-1 replication to help decide whether to interrupt antiretroviral treatment. They may be related to control of HIV replication as well as to pathogenesis of infection, perhaps in setting the balance between immunity or tolerance to the virus. A better understanding of these parameters is required while attempts to use IFN-alpha or ligands of Toll-like receptors found on pDC are being made.

Role for plasmacytoid dendritic cells in anti-HIV innate immunity. Publishing Authors By Initials

M ,A Hosmalin,M ,A Hosmalin,

For similar biological phenomena, cell phenomena, and immunity: immunity: immunity, natural research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: immunity, natural research

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Role for plasmacytoid dendritic cells in anti-HIV innate immunity. Journal Published:

PUBLICATION TYPE: Review

Journal: Immunology and cell biology

VOLUME: 83

Page Numbers: 578-83

Journal Abbreviation: Immunol. Cell Biol.

ISSN: 0818-9641

DAY: 3

MONTH: Oct

YEAR: 2005

Role for plasmacytoid dendritic cells in anti-HIV innate immunity. Information

Number of References: 108

LANGUAGE: eng

NlmUniqueID: 8706300

Role for plasmacytoid dendritic cells in anti-HIV innate immunity. Keywords Mesh Terms:

KEYWORDS: Immunity, Natural

MESH TERMS: immunology

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Grant and Affiliation Information for Role for plasmacytoid dendritic cells in anti-HIV innate immunity.

AFFILIATION: Unité de Biologie des Rétrovirus, Institut Pasteur, Université Paris V René Descartes, Paris, France.

Country: Australia

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MEDLINETA: Immunol Cell Biol

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