Robustness analysis identifies the plausible model of the Bcl-2 apoptotic switch.

Robustness analysis identifies the plausible model of the Bcl-2 apoptotic switch. Research Abstract Details 

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Robustness analysis identifies the plausible model of the Bcl-2 apoptotic switch. Abstract Text:

Chun Chen,Jun Cui,Wei Zhang,Pingping Shen,Chun Chen,Jun Cui,Wei Zhang,Pingping Shen,

In this paper two competing models of the B-cell lymphoma 2 (Bcl-2) apoptotic switch were contrasted by mathematical modeling and robustness analysis. Since switch-like behaviors are required for models that attempt to explain the all-or-none decisions of apoptosis, ultrasensitivity was employed as a criterion for comparison. Our results successfully exhibit that the direct activation model operates more reliably to achieve a robust switch in cellular conditions. Moreover, by investigating the robustness of other important features of the Bcl-2 apoptotic switch (including low Bax basal activation, inhibitory role of anti-apoptotic proteins and insensitivity to small perturbations) the direct activation model was further supported. In all, we identified the direct activation model as a more plausible explanation for the Bcl-2 apoptotic switch.

Robustness analysis identifies the plausible model of the Bcl-2 apoptotic switch. Publishing Authors By Initials

C Chen,J Cui,W Zhang,P Shen,C Chen,J Cui,W Zhang,P Shen,

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Robustness analysis identifies the plausible model of the Bcl-2 apoptotic switch. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: FEBS letters

VOLUME: 581

Page Numbers: 5143-50

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 8

MONTH: 10

YEAR: 2007

Robustness analysis identifies the plausible model of the Bcl-2 apoptotic switch. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Robustness analysis identifies the plausible model of the Bcl-2 apoptotic switch.

AFFILIATION: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, People's Republic of China.

Country: Netherlands

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MEDLINETA: FEBS Lett

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