Robust Score Statistics for QTL Linkage Analysis.

Robust Score Statistics for QTL Linkage Analysis. Research Abstract Details 

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Robust Score Statistics for QTL Linkage Analysis. Abstract Text:

Samsiddhi Bhattacharjee,Chia-Ling Kuo,Nandita Mukhopadhyay,Guy N Brock,Daniel E Weeks,Eleanor Feingold,

The traditional variance components approach for quantitative trait locus (QTL) linkage analysis is sensitive to violations of normality and fails for selected sampling schemes. Recently, a number of new methods have been developed for QTL mapping in humans. Most of the new methods are based on score statistics or regression-based statistics and are expected to be relatively robust to non-normality of the trait distribution and also to selected sampling, at least in terms of type I error. Whereas the theoretical development of these statistics is more or less complete, some practical issues concerning their implementation still need to be addressed. Here we study some of these issues such as the choice of denominator variance estimates, weighting of pedigrees, effect of parameter misspecification, effect of non-normality of the trait distribution, and effect of incorporating dominance. We present a comprehensive discussion of the theoretical properties of various denominator variance estimates and of the weighting issue and then perform simulation studies for nuclear families to compare the methods in terms of power and robustness. Based on our analytical and simulation results, we provide general guidelines regarding the choice of appropriate QTL mapping statistics in practical situations.

Robust Score Statistics for QTL Linkage Analysis. Publishing Authors By Initials

S Bhattacharjee,CL Kuo,N Mukhopadhyay,GN Brock,DE Weeks,E Feingold,

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Robust Score Statistics for QTL Linkage Analysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of human genetics

VOLUME: 82

Page Numbers: 567-82

Journal Abbreviation: Am. J. Hum. Genet.

ISSN: 1537-6605

DAY: 21

MONTH: 02

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Country: United States

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MEDLINETA: Am J Hum Genet

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