Robo4 is a vascular-specific receptor that inhibits endothelial migration.

Robo4 is a vascular-specific receptor that inhibits endothelial migration. Research Abstract Details 

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Robo4 is a vascular-specific receptor that inhibits endothelial migration. Abstract Text:

Kye Won Park,Clayton M Morrison,Lise K Sorensen,Christopher A Jones,Yi Rao,Chi-Bin Chien,Jane Y Wu,Lisa D Urness,Dean Y Li,Kye Won Park,Clayton M Morrison,Lise K Sorensen,Christopher A Jones,Yi Rao,Chi-Bin Chien,Jane Y Wu,Lisa D Urness,Dean Y Li,

Guidance and patterning of axons are orchestrated by cell-surface receptors and ligands that provide directional cues. Interactions between the Robo receptor and Slit ligand families of proteins initiate signaling cascades that repel axonal outgrowth. Although the vascular and nervous systems grow as parallel networks, the mechanisms by which the vascular endothelial cells are guided to their appropriate positions remain obscure. We have identified a putative Robo homologue, Robo4, based on its differential expression in mutant mice with defects in vascular sprouting. In contrast to known neuronal Robo family members, the arrangement of the extracellular domains of Robo4 diverges significantly from that of all other Robo family members. Moreover, Robo4 is specifically expressed in the vascular endothelium during murine embryonic development. We show that Robo4 binds Slit and inhibits cellular migration in a heterologous expression system, analogous to the role of known Robo receptors in the nervous system. Immunoprecipitation studies indicate that Robo4 binds to Mena, a known effector of Robo-Slit signaling. Finally, we show that Robo4 is the only Robo family member expressed in primary endothelial cells and that application of Slit inhibits their migration. These data demonstrate that Robo4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development.

Robo4 is a vascular-specific receptor that inhibits endothelial migration. Publishing Authors By Initials

KW Park,CM Morrison,LK Sorensen,CA Jones,Y Rao,CB Chien,JY Wu,LD Urness,DY Li,KW Park,CM Morrison,LK Sorensen,CA Jones,Y Rao,CB Chien,JY Wu,LD Urness,DY Li,

For similar animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research abstracts see: animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research

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Robo4 is a vascular-specific receptor that inhibits endothelial migration. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Developmental biology

VOLUME: 261

Page Numbers: 251-67

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 1

MONTH: Sep

YEAR: 2003

Robo4 is a vascular-specific receptor that inhibits endothelial migration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372762

Robo4 is a vascular-specific receptor that inhibits endothelial migration. Keywords Mesh Terms:

KEYWORDS: Zebrafish

MESH TERMS: physiology

Chemical & Substance for Abstract: Robo4 is a vascular-specific receptor that inhibits endothelial migration. Information

Substance Name: ACVRL1 protein, human

Registry Number: EC 2.7.11.30

Grant and Affiliation Information for Robo4 is a vascular-specific receptor that inhibits endothelial migration.

AFFILIATION: School of Medicine, University of Utah, Salt Lake City, UT 84112, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM070967-02

ACRONYM: GM

MEDLINETA: Dev Biol

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