RNAi silencing in mouse models of neurodegenerative diseases.

RNAi silencing in mouse models of neurodegenerative diseases. Research Abstract Details 

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RNAi silencing in mouse models of neurodegenerative diseases. Abstract Text:

Mohamed H Farah,

RNA interference (RNAi) has emerged as a potential therapeutic approach for neurodegenerative diseases, particularly those associated with autosomal dominant patterns of inheritance. In proof of concept experiments, several groups have demonstrated efficacy of using viral vectors expressing short hairpin RNA (shRNA) directed against therapeutically relevant genes in mouse models of neurodegenerative diseases, including spinocerebellar ataxia, Amyotrophic Lateral Sclerosis, Huntington's Disease and amyloidosis (a pathological aspect of Alzheimer's Disease). Although viral-based RNAi has limitations that most likely will preclude its usage in humans, a few recent developments underscore the potential of non-viral-based delivery of relevant RNAi as therapeutics for neurodegenerative diseases. Here, I will review the recent literature on effectiveness of RNAi as a therapeutic strategy in mouse models of neurodegenerative diseases.

RNAi silencing in mouse models of neurodegenerative diseases. Publishing Authors By Initials

MH Farah,

For similar enzymes and coenzymes: enzymes: oxidoreductases: superoxide dismutase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: superoxide dismutase research

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RNAi silencing in mouse models of neurodegenerative diseases. Journal Published:

PUBLICATION TYPE: Review

Journal: Current drug delivery

VOLUME: 4

Page Numbers: 161-7

Journal Abbreviation:

ISSN: 1567-2018

DAY: 3

MONTH: Apr

YEAR: 2007

RNAi silencing in mouse models of neurodegenerative diseases. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101208455

RNAi silencing in mouse models of neurodegenerative diseases. Keywords Mesh Terms:

KEYWORDS: Superoxide Dismutase

MESH TERMS: metabolism

Chemical & Substance for Abstract: RNAi silencing in mouse models of neurodegenerative diseases. Information

Substance Name: Bace1 protein, mouse

Registry Number: EC 3.4.23.46

Grant and Affiliation Information for RNAi silencing in mouse models of neurodegenerative diseases.

AFFILIATION: Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA. mfarah2@jhem.jhmi.edu

Country: United Arab Emirates

AGENCY: United States NIA

GRANT: AG025658

ACRONYM: AG

MEDLINETA: Curr Drug Deliv

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