Rnai activity of sirnas modified with 2'-aminoalkyl-substituted fluorinated nucleobases.

Rnai activity of sirnas modified with 2'-aminoalkyl-substituted fluorinated nucleobases. Research Abstract Details 

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Rnai activity of sirnas modified with 2'-aminoalkyl-substituted fluorinated nucleobases. Abstract Text:

Jens Haas,Thea Mueller-Kuller,Stefan Klein,Joachim W Engels,Jens Haas,Thea Mueller-Kuller,Stefan Klein,Joachim W Engels,Jens Haas,Thea Mueller-Kuller,Stefan Klein,Joachim W Engels,Jens Haas,Thea Mueller-Kuller,Stefan Klein,Joachim W Engels,

We recently reported that a 1'-deoxy-1'-(4,6-difluoro-1H-benzimidazol-1-yl)-2'-(beta-aminoethyl)-beta-d-ribofuranose nucleoside appears to be a universal nucleoside which does not differentiate between the four natural nucleosides A, C, G, and U in duplexes. Moreover, ribozymes modified with this nucleoside analog showed a better or at least equal catalytic activity relative to Watson-Crick mismatches.([)(1)(]) Due to these data, we investigated the ability of this compound to tolerate Watson-Crick mismatches in order to avoid HIV escape mutations in RNA interference. The influence of this nucleoside analog on siRNA efficiency was analyzed with a proven siRNA targeting GFP.

Rnai activity of sirnas modified with 2'-aminoalkyl-substituted fluorinated nucleobases. Publishing Authors By Initials

J Haas,T Mueller-Kuller,S Klein,JW Engels,J Haas,T Mueller-Kuller,S Klein,JW Engels,J Haas,T Mueller-Kuller,S Klein,JW Engels,J Haas,T Mueller-Kuller,S Klein,JW Engels,

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Rnai activity of sirnas modified with 2'-aminoalkyl-substituted fluorinated nucleobases. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nucleosides, nucleotides & nucleic acids

VOLUME: 26

Page Numbers: 865-8

Journal Abbreviation: Nucleosides Nucleotides Nuclei

ISSN: 1525-7770

DAY: 10

MONTH: 12

YEAR: 2007

Rnai activity of sirnas modified with 2'-aminoalkyl-substituted fluorinated nucleobases. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Rnai activity of sirnas modified with 2'-aminoalkyl-substituted fluorinated nucleobases.

AFFILIATION: Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.

Country: United States

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MEDLINETA: Nucleosides Nucleotides Nuclei

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