RNA editing in Trypanosoma brucei requires three different editosomes.

RNA editing in Trypanosoma brucei requires three different editosomes. Research Abstract Details 

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RNA editing in Trypanosoma brucei requires three different editosomes. Abstract Text:

Jason Carnes,James Raffaello Trotter,Adam Peltan,Michele Fleck,Kenneth Stuart,Jason Carnes,James Raffaello Trotter,Adam Peltan,Michele Fleck,Kenneth Stuart,Jason Carnes,James Raffaello Trotter,Adam Peltan,Michele Fleck,Kenneth Stuart,

Trypanosoma brucei has three distinct approximately 20S editosomes that catalyze RNA editing by the insertion and deletion of uridylates. Editosomes with the KREN1 or KREN2 RNase III type endonucleases specifically cleave deletion and insertion editing site substrates, respectively. We report here that editosomes with KREPB2, which also has an RNase III motif, specifically cleave cytochrome oxidase II (COII) pre-mRNA insertion editing site substrates in vitro. Conditional repression and mutation studies also show that KREPB2 is an editing endonuclease specifically required for COII mRNA editing in vivo. Furthermore, KREPB2 expression is essential for the growth and survival of bloodstream forms. Thus, editing in T. brucei requires at least three compositionally and functionally distinct approximately 20S editosomes, two of which distinguish between different insertion editing sites. This unexpected finding reveals an additional level of complexity in the RNA editing process and suggests a mechanism for how the selection of sites for editing in vivo is controlled.

RNA editing in Trypanosoma brucei requires three different editosomes. Publishing Authors By Initials

J Carnes,JR Trotter,A Peltan,M Fleck,K Stuart,J Carnes,JR Trotter,A Peltan,M Fleck,K Stuart,J Carnes,JR Trotter,A Peltan,M Fleck,K Stuart,

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RNA editing in Trypanosoma brucei requires three different editosomes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular biology

VOLUME: 28

Page Numbers: 122-30

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 1098-5549

DAY: 22

MONTH: 10

YEAR: 2007

RNA editing in Trypanosoma brucei requires three different editosomes. Information

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LANGUAGE: eng

NlmUniqueID: 8109087

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Grant and Affiliation Information for RNA editing in Trypanosoma brucei requires three different editosomes.

AFFILIATION: Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA 98109, USA.

Country: United States

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MEDLINETA: Mol Cell Biol

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