RNA editing in Drosophila melanogaster: New targets and functional consequences.

RNA editing in Drosophila melanogaster: New targets and functional consequences. Research Abstract Details 

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RNA editing in Drosophila melanogaster: New targets and functional consequences. Abstract Text:

Mark Stapleton,Joseph W Carlson,Susan E Celniker,

Adenosine deaminases that act on RNA [adenosine deaminase, RNA specific (ADAR)] catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts. These re-coding events affect coding potential, splice sites, and stability of mature mRNAs. ADAR is an essential gene, and studies in mouse, Caenorhabditis elegans, and Drosophila suggest that its primary function is to modify adult behavior by altering signaling components in the nervous system. By comparing the sequence of isogenic cDNAs to genomic DNA, we have identified and experimentally verified 27 new targets of Drosophila ADAR. Our analyses led us to identify new classes of genes whose transcripts are targets of ADAR, including components of the actin cytoskeleton and genes involved in ion homeostasis and signal transduction. Our results indicate that editing in Drosophila increases the diversity of the proteome, and does so in a manner that has direct functional consequences on protein function.

RNA editing in Drosophila melanogaster: New targets and functional consequences. Publishing Authors By Initials

M Stapleton,JW Carlson,SE Celniker,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

PUBMED ID PMID:

MEDLINE DATE:

RNA editing in Drosophila melanogaster: New targets and functional consequences. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: RNA (New York, N.Y.)

VOLUME: 12

Page Numbers: 1922-32

Journal Abbreviation: RNA

ISSN: 1355-8382

DAY: 3

MONTH: 10

YEAR: 2006

RNA editing in Drosophila melanogaster: New targets and functional consequences. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9509184

RNA editing in Drosophila melanogaster: New targets and functional consequences. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: genetics

Chemical & Substance for Abstract: RNA editing in Drosophila melanogaster: New targets and functional consequences. Information

Substance Name: Adenosine Deaminase

Registry Number: EC 3.5.4.4

Grant and Affiliation Information for RNA editing in Drosophila melanogaster: New targets and functional consequences.

AFFILIATION: Berkeley Drosophila Genome Project, Department of Genome Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. staple@fruitfly.org

Country: United States

AGENCY: United States NHGRI

GRANT: HG002673

ACRONYM: HG

MEDLINETA: RNA

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