Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction.

Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction. Research Abstract Details 

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Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction. Abstract Text:

Jennifer L Rudolph,Geng-Xian Shi,Eda Erdogan,Alan P Fields,Douglas A Andres,Jennifer L Rudolph,Geng-Xian Shi,Eda Erdogan,Alan P Fields,Douglas A Andres,Jennifer L Rudolph,Geng-Xian Shi,Eda Erdogan,Alan P Fields,Douglas A Andres,

Rit is a novel member of the Ras superfamily of small GTP-binding proteins that regulates signaling pathways controlling cellular fate determination. Constitutively activated mutants of Rit induce terminal differentiation of pheochromocytoma (PC6) cells resulting in a sympathetic neuron-like phenotype characterized by the development of highly-branched neurites. Rit signaling has been found to activate several downstream pathways including MEK/ERK, p38 MAPK, Ral-specific guanine nucleotide exchange factors (GEFs), and Rit associates with the Par6 cell polarity machinery. In this study, a series of Rit effector loop mutants was generated to test the importance of these cellular targets to Rit-mediated neuronal differentiation. We find that Rit-mediated neuritogenesis is dependent upon MEK/ERK MAP kinase signaling but independent of RalGEF activation. In addition, in vivo binding studies identified a novel mechanism of Par6 interaction, suggesting that the cell polarity machinery may serve to spatially restrict Rit signaling.

Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction. Publishing Authors By Initials

JL Rudolph,GX Shi,E Erdogan,AP Fields,DA Andres,JL Rudolph,GX Shi,E Erdogan,AP Fields,DA Andres,JL Rudolph,GX Shi,E Erdogan,AP Fields,DA Andres,

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Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochimica et biophysica acta

VOLUME: 1773

Page Numbers: 1793-800

Journal Abbreviation: Biochim. Biophys. Acta

ISSN: 0006-3002

DAY: 9

MONTH: 10

YEAR: 2007

Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction.

AFFILIATION: Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, 741 South Limestone Street, Lexington, KY 40536-0509, USA.

Country: Netherlands

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MEDLINETA: Biochim Biophys Acta

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