Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe.

Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe. Abstract Text:

Diego Serraino,Pierluca Piselli,Ghil Busnach,Patrizia Burra,Franco Citterio,Eloisa Arbustini,Umberto Baccarani,Emanuela De Juli,Ubaldo Pozzetto,Stefania Bellelli,Jerry Polesel,Christian Pradier,Luigino Dal Maso,Claudio Angeletti,Maria Patrizia Carrieri,Giovanni Rezza,Silvia Franceschi, ,Diego Serraino,Pierluca Piselli,Ghil Busnach,Patrizia Burra,Franco Citterio,Eloisa Arbustini,Umberto Baccarani,Emanuela De Juli,Ubaldo Pozzetto,Stefania Bellelli,Jerry Polesel,Christian Pradier,Luigino Dal Maso,Claudio Angeletti,Maria Patrizia Carrieri,Giovanni Rezza,Silvia Franceschi, ,

This investigation highlighted the risk of cancer in 8074 HIV-infected people and in 2875 transplant recipients in Italy and France. Observed and expected numbers of cancer were compared through sex- and age-standardised incidence ratios (SIRs) and 95% confidence intervals (CIs). After 15 years of follow-up, the cumulative probability of cancer was 14.7% in transplant recipients and 13.3% in HIV-positives. The SIRs for all cancers were 9.8 in HIV-positives and 2.2 in transplants. Kaposi's sarcoma (SIR=451 in HIV-positives, 125 in transplants) and non-Hodgkin lymphoma (SIR=62 and 11.1, respectively) were the most common cancers. A significantly increased SIR for liver cancer also emerged in both groups. The risk of lung cancer was significantly elevated in heart transplant recipients (SIR=2.8), and of borderline statistical significance in HIV-positive people (95% CI:0.9-2.8). Immune depression entails a two-fold increased overall risk of cancers, mainly related to cancers associated with a viral aetiology.

Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe. Publishing Authors By Initials

D Serraino,P Piselli,G Busnach,P Burra,F Citterio,E Arbustini,U Baccarani,E De Juli,U Pozzetto,S Bellelli,J Polesel,C Pradier,L Dal Maso,C Angeletti,MP Carrieri,G Rezza,S Franceschi, ,D Serraino,P Piselli,G Busnach,P Burra,F Citterio,E Arbustini,U Baccarani,E De Juli,U Pozzetto,S Bellelli,J Polesel,C Pradier,L Dal Maso,C Angeletti,MP Carrieri,G Rezza,S Franceschi, ,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of cancer (Oxford, England : 1990

VOLUME: 43

Page Numbers: 2117-23

Journal Abbreviation: Eur. J. Cancer

ISSN: 0959-8049

DAY: 30

MONTH: 08

YEAR: 2007

Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9005373

Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe.

AFFILIATION: Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, via F Gallini, 2, 33081 Aviano (PN), Italy. serrainod@cro.it

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Cancer

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe Related Publications

• A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (a/g)-308 polymorphism.
• A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene.
• Analysis of transcription factor interactions in osteoblasts using competitive chromatin immunoprecipitation.
• Back to the future: the ribosome as an antibiotic target.
• Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells.
• Chapter 27: Research needs following initial licensure of virus-like particle HPV vaccines.
• Common evolutionary origin of the immune and neuroendocrine systems: from morphological and functional evidence to in silico approaches.
• Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development.
• Daunorubicin and daunorubicinol tissue concentrations in gastric cancer patients after local administration of a liposomal preparation.
• Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach.
• Erythrocyte plasma membranes obtained from centenarians show different functional properties.
• Healing Cranial Defects with AdRunx2-transduced Marrow Stromal Cells.
• Human longevity within an evolutionary perspective: The peculiar paradigm of a post-reproductive genetics.
• Human papillomavirus infection in women with and without cervical cancer in Warsaw, Poland.
• Human papillomavirus types among women infected with HIV: a meta-analysis.
• Immunoproteasome in Macaca fascicularis: No Age-Dependent Modification of Abundance and Activity in the Brain and Insight into an in silico Structural Model.
• In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation.
• Incidence of primary liver cancer in Italy between 1988 and 2002: An age-period-cohort analysis.
• Inflammaging as a major characteristic of old people: can it be prevented or cured?
• Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood.
• Members of the human papillomavirus type 18 family (alpha-7 species) share a common association with adenocarcinoma of the cervix.
• New molecular targets and novel anticancer treatments: emerging trends in neuro-oncology.
• Paraoxonase 1: genetics and activities during aging.
• Plasma concentrations of interleukin-1-beta, interleukin-6 and tumor necrosis factor-alpha, and of their soluble receptors and receptor antagonist in anorexia nervosa.
• Prevalence of hepatitis B and C serological markers among first-time blood donors in Brazil: a multi-center serosurvey.
• Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe.
• Serologic response to oncogenic human papillomavirus types in male and female university students in Busan, South Korea.
• The IARC commitment to cancer prevention: the example of papillomavirus and cervical cancer.
• Use of a stringent dimerizer-regulated gene expression system for controlled BMP2 delivery.
• Usefulness of the comprehensive geriatric assessment in older patients with upper gastrointestinal bleeding: a two-year follow-up study.