Risk factors predicting residual disease in subsequent hysterectomy following conization for cervical intraepithelial neoplasia (CIN) III and microinvasive cervical cancer.

Risk factors predicting residual disease in subsequent hysterectomy following conization for cervical intraepithelial neoplasia (CIN) III and microinvasive cervical cancer. Research Abstract Details 

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Risk factors predicting residual disease in subsequent hysterectomy following conization for cervical intraepithelial neoplasia (CIN) III and microinvasive cervical cancer. Abstract Text:

Jeong-Yeol Park,Seung Mi Lee,Chong Woo Yoo,Sokbom Kang,Sang-Yoon Park,Sang-Soo Seo,

OBJECTIVE: To determine factors predicting post-cone residual disease in cervical intraepithelial neoplasia (CIN) III and microinvasive cervical cancer. METHODS: Of 337 patients who underwent conization due to CIN III and microinvasive cervical cancer between November 2001 and March 2006, 77 underwent hysterectomy within 6 months of conization. We analyzed their demographic features, pathologic parameters and pre-cone high-risk human papilloma virus (HR-HPV) load measured by Digene Hybrid Capture II. RESULTS: In univariate analysis, age >or=50 years (P=0.048, relative risk [RR]=2.74, 95% confidence interval [CI]=1.0-7.4), positive resection margin (P=0.004, RR=4.35, 95% CI=1.5-12.3), and pre-cone HR-HPV load >or=300 relative light units (RLU)/positive control (PC) (P=0.009, RR=3.41, 95% CI=1.3-8.7) were significant factors associated with residual disease. While postmenopausal status showed borderline significance (P=0.065, RR=2.65, 95% CI=0.9-7.5), parity >or=3, severity of disease (CIN III vs. microinvasive cancer), conization method (large loop excision of transformation zone vs. cold knife conization), and glandular extension were not significant. In multivariate analysis only positive margin (P=0.023, RR=3.56, 95% CI=1.2-10.7) and pre-cone HR-HPV load >or=300 RLU/PC (P=0.034, RR=2.96, 95% CI=1.1-8.1) were significant factors associated with residual disease. CONCLUSION: Positive margin and pre-cone HR-HPV load >or=300 RLU/PC were the only significant factors predicting post-cone residual disease in multivariate analysis. Appropriate application of these predictive factors may avoid post-cone hysterectomy.

Risk factors predicting residual disease in subsequent hysterectomy following conization for cervical intraepithelial neoplasia (CIN) III and microinvasive cervical cancer. Publishing Authors By Initials

JY Park,SM Lee,CW Yoo,S Kang,SY Park,SS Seo,

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Risk factors predicting residual disease in subsequent hysterectomy following conization for cervical intraepithelial neoplasia (CIN) III and microinvasive cervical cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gynecologic oncology

VOLUME: 107

Page Numbers: 39-44

Journal Abbreviation: Gynecol. Oncol.

ISSN: 0090-8258

DAY: 19

MONTH: 06

YEAR: 2007

Risk factors predicting residual disease in subsequent hysterectomy following conization for cervical intraepithelial neoplasia (CIN) III and microinvasive cervical cancer. Information

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LANGUAGE: eng

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AFFILIATION: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, 809 Madu1-dong, Ilsan-gu, Goyang-si, Gyeonggi-do, 411-351, Korea.

Country: United States

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MEDLINETA: Gynecol Oncol

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