Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study.

Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study. Research Abstract Details 

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Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study. Abstract Text:

Jiali Han,Graham A Colditz,David J Hunter,

BACKGROUND: Constitutional factors and sun exposure are associated with skin cancer risk. However, these relations are complex and differ according to skin cancer type. METHODS: We examined the associations of constitutional risk factors and sun exposure with the risks of three types of skin cancer simultaneously and evaluated the interaction between constitutional susceptibility and sun exposure in a nested case-control study within the Nurses' Health Study [200 melanoma, 275 squamous cell carcinoma (SCC), and 283 basal cell carcinoma (BCC) cases, and 804 controls]. Information regarding skin cancer risk factors was obtained from the retrospective supplementary questionnaire. RESULTS: Constitutional susceptibility was an independent risk factor for all three types of skin cancer. Sunlamp usage or tanning salon attendance was a risk factor for melanoma after adjusting for potential confounding variables (OR for ever vs never usage, 2.06, 95% CI 1.30-3.26). Higher sun exposure while wearing a bathing suit was an independent risk factor for all three types of skin cancer. We observed a significant interaction between constitutional susceptibility and sun exposure while wearing a bathing suit on melanoma risk (P, interaction, 0.03); women with the highest susceptibility and highest exposure had an OR of 8.37 (95% CI 3.07-22.84). This interaction was weaker and non-significant for SCC and BCC. CONCLUSIONS: These data largely confirm past studies on risk factors for skin cancer but provide evidence of difference on the strength of these risk factors for melanoma compared with SCC and BCC.

Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study. Publishing Authors By Initials

J Han,GA Colditz,DJ Hunter,

For similar environment and public health: environment: meteorological factors: atmosphere: weather: sunlight research abstracts see: environment and public health: environment: meteorological factors: atmosphere: weather: sunlight research

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Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of epidemiology

VOLUME: 35

Page Numbers: 1514-21

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ISSN: 0300-5771

DAY: 30

MONTH: 08

YEAR: 2006

Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study. Information

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LANGUAGE: eng

NlmUniqueID: 7802871

Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study. Keywords Mesh Terms:

KEYWORDS: Sunlight

MESH TERMS: adverse effects

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Grant and Affiliation Information for Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study.

AFFILIATION: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. jiali.han@channing.harvard.edu

Country: England

AGENCY: United States NCI

GRANT: CA87969

ACRONYM: CA

MEDLINETA: Int J Epidemiol

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