RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR.

RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR. Abstract Text:

D B Ramnarain,R Paulmurugan,S Park,B E Mickey,A Asaithamby,D Saha,M A Kelliher,P Mukhopadhyay,F Banani,C J Madden,P S Wright,S Chakravarty,A A Habib,D B Ramnarain,R Paulmurugan,S Park,B E Mickey,A Asaithamby,D Saha,M A Kelliher,P Mukhopadhyay,F Banani,C J Madden,P S Wright,S Chakravarty,A A Habib,

There is considerable interest in understanding how inflammatory responses influence cell proliferation and cancer. In this study, we show that the receptor-interacting protein (RIP1), a critical mediator of inflammation and stress-induced NF-kappaB activation, regulates the expression of the epidermal growth factor receptor (EGFR). Mouse embryo fibroblasts (MEFs) derived from RIP1 knockout mice express very high levels of the EGFR. Reconstitution of RIP1(-/-) MEFs with RIP1 results in a lowering of EGFR levels. RIP1 influences EGFR at the mRNA level by regulating the EGFR promoter. Expression of RIP1 inhibits the EGFR promoter. RIP1 downregulates EGFR expression by interfering with the function of Sp1, which is a key activator of EGFR transcription. RIP1 suppresses Sp1 activity and overexpression of Sp1 reverses RIP1-mediated repression of the EGFR promoter. RIP1 is present both in the cytoplasm and in the nucleus. RIP1 coimmunoprecipitates with Sp1 in vivo and binds directly to Sp1 in vitro. A RIP1 mutant lacking the death domain fails to suppress Sp1 activity and the EGFR promoter, suggesting a critical role for the RIP1 death domain in EGFR regulation. Thus, our study identifies a new link between inflammatory and growth factor signaling pathways mediated by RIP1 and provides insight into the mechanism used by RIP1 to regulate EGFR levels.Cell Death and Differentiation (2008) 15, 344-353; doi:10.1038/sj.cdd.4402268; published online 16 November 2007.

RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR. Publishing Authors By Initials

DB Ramnarain,R Paulmurugan,S Park,BE Mickey,A Asaithamby,D Saha,MA Kelliher,P Mukhopadhyay,F Banani,CJ Madden,PS Wright,S Chakravarty,AA Habib,DB Ramnarain,R Paulmurugan,S Park,BE Mickey,A Asaithamby,D Saha,MA Kelliher,P Mukhopadhyay,F Banani,CJ Madden,PS Wright,S Chakravarty,AA Habib,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell death and differentiation

VOLUME: 15

Page Numbers: 344-53

Journal Abbreviation: Cell Death Differ.

ISSN: 1350-9047

DAY: 16

MONTH: 11

YEAR: 2007

RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9437445

RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR.

AFFILIATION: 1Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cell Death Differ

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR Related Publications

• Action of thiosulphate on the kidney of the cat.
• Acute post-operative infective endophthalmitis detected on first-day check.
• Alkaloids from Senecio aegyptius and S. desfontainei.
• Characterization and clinical application of human CD34+ stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor.
• Classification of glomerulonephropathies.
• Combining pulse oximetry and clinical examination in screening for congenital heart disease.
• Controlled biological and biomimetic systems for landmine detection.
• Cutaneous mononuclear cells and eosinophils are significantly increased after warm water challenge in pruritic areas of polycythemia vera.
• Ethnicity and the distance to the epidural space in parturients.
• Impact of cerebrovascular complications on mortality and neurologic outcome during infective endocarditis: a prospective multicentre study.
• Knife-edge scanning of an astigmatic Gaussian beam.
• Maternal serum alpha-feto-protein: its value in antenatal diagnosis of genetic disease and in obstetrical-gynaecological care.
• Optical resonator with an external source: excitation of the Hermite-Gaussian modes.
• Optimal target vessel stenosis for radial artery grafting.
• Perinatal depression: hiding in plain sight.
• Polymorphisms of TNF-enhancer and gene for FcgammaRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population.
• RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR.
• Response to the comments by Gandolfo et al. on 'The flow cytometric analysis of premalignant and malignant lesions in head and neck squamous cell carcinoma published on oral oncology'.
• The insulin-like growth factor type 1 receptor and colorectal neoplasia: insights into invasion.
• The role of chromosomal aberrations in premalignant and malignant lesions in head and neck squamous cell carcinoma.
• Traumatic wound dehiscence of old extracapsular cataract extraction incision after endothelial keratoplasty.
• Unpredictability of delivered bubble nasal continuous positive airway pressure: role of bias flow magnitude and nares-prong air leaks.
• [Aspects of hysteria in Lebanon]
• [Chronic bronchitis in Lebanon]
• [Clinical trials of the new phenothiazine derivative, RP-7843 (Majeptil) in states of agitation.]
• [Mitochondrial cardiomyopathy in an adult: a case history.]
• [Norplant and its side effects]
• [Phenelzine (Nardil) in the depressive syndrome. Clinical impression.]
• [The place of the pneuperitoneum in the treatment of pulmonary tuberculosis.]
• [Tuberculin with antibiotics in the treatment of pulmonary tuberculosis.]