Rigidity and catalepsy after injections of muscimol into the ventromedial thalamic nucleus: an electromyographic study in the rat.

Rigidity and catalepsy after injections of muscimol into the ventromedial thalamic nucleus: an electromyographic study in the rat. Research Abstract Details 

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Rigidity and catalepsy after injections of muscimol into the ventromedial thalamic nucleus: an electromyographic study in the rat. Abstract Text:

T Klockgether,M Schwarz,L Turski,S Wolfarth,K H Sontag,

The cataleptic state induced by injection of the GABAmimetic drug muscimol into the rat's ventromedial thalamic nucleus (VM) was examined using an electromyographic (EMG) approach. Muscimol in doses up to 50 ng/0.5 microliter injected into the VM induced a tonic EMG activity in the gastrocnemius muscle which is considered to be a measure of limb rigidity. This tonic EMG activity was found to be dose-dependent, GABA specific and locus specific. By recording EMG signals from chronically implanted electrodes in awake, unrestrained rats it was shown that muscular reactions serving to maintain the animal's static equilibrium were intact in the state of VM induced catalepsy. However, animals were unable to initiate movements or locomotion even when they were forced by strong external stimuli. It was found that the animals' immobility was due to an inability to induce a phasic activation of their muscles whereas tonic activation still occurred. It is concluded that the rat's VM is part of a neuronal chain conducting information relevant for the expression of limb rigidity, the VM is involved in the central mechanisms responsible for the phasic activation of a set of muscles.

Rigidity and catalepsy after injections of muscimol into the ventromedial thalamic nucleus: an electromyographic study in the rat. Publishing Authors By Initials

T Klockgether,M Schwarz,L Turski,S Wolfarth,KH Sontag,

For similar nervous system: central nervous system: brain: prosencephalon: diencephalon: thalamus: thalamic nuclei research abstracts see: nervous system: central nervous system: brain: prosencephalon: diencephalon: thalamus: thalamic nuclei research

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Rigidity and catalepsy after injections of muscimol into the ventromedial thalamic nucleus: an electromyographic study in the rat. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 58

Page Numbers: 559-69

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ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1985

Rigidity and catalepsy after injections of muscimol into the ventromedial thalamic nucleus: an electromyographic study in the rat. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Rigidity and catalepsy after injections of muscimol into the ventromedial thalamic nucleus: an electromyographic study in the rat. Keywords Mesh Terms:

KEYWORDS: Thalamic Nuclei

MESH TERMS: drug effects

Chemical & Substance for Abstract: Rigidity and catalepsy after injections of muscimol into the ventromedial thalamic nucleus: an electromyographic study in the rat. Information

Substance Name: Bicuculline

Registry Number: 485-49-4

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Country: GERMANY, WEST

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MEDLINETA: Exp Brain Res

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