Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute.

Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Research Abstract Details 

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Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Abstract Text:

Ribosomal protein mutations, termed Minutes, have been instrumental in studying the coordination of cell and tissue growth in Drosophila. Although abundant in flies, equivalent defects in mammals are relatively unknown. Belly spot and tail (Bst) is a semidominant mouse mutation that disrupts pigmentation, somitogenesis and retinal cell fate determination. Here, we identify Bst as a deletion within the Rpl24 riboprotein gene. Bst significantly impairs Rpl24 splicing and ribosome biogenesis. Bst/+ cells have decreased rates of protein synthesis and proliferation, and are outcompeted by wild-type cells in C57BLKS<-->ROSA26 chimeras. Bacterial artificial chromosome (BAC) and cDNA transgenes correct the mutant phenotypes. Our findings establish Bst as a mouse Minute and provide the first detailed characterization of a mammalian ribosomal protein mutation.

Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Publishing Authors By Initials

For similar animal structures: tail research abstracts see: animal structures: tail research

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Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Development (Cambridge, England)

VOLUME: 131

Page Numbers: 3907-20

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 6

MONTH: Aug

YEAR: 2004

Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8701744

Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Keywords Mesh Terms:

KEYWORDS: Tail

MESH TERMS: abnormalities

Chemical & Substance for Abstract: Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Information

Substance Name: ribosomal protein L24

Registry Number: 0

Grant and Affiliation Information for Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute.

AFFILIATION: Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Country: England

AGENCY: United States NIGMS

GRANT: T32 GM07863

ACRONYM: GM

MEDLINETA: Development

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