Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid.

Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid. Research Abstract Details 

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Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid. Abstract Text:

Scott E Feller,Klaus Gawrisch,Thomas B Woolf,

An all-atom molecular dynamics simulation of rhodopsin in a membrane environment has been carried out with lipid composition similar to that of the retinal membrane. The initial conformation of the protein was taken from the X-ray crystallographic structure (1F88), while those of the lipids came from a previous molecular dynamics simulation. During the course of the 12.5 ns simulation, the initially randomly placed lipids adopt an anisotropic solvation structure around the protein. The lipids, having one saturated stearic acid chain and one polyunsaturated docosohexaenoic acid chain with a zwitterionic phosphatidylcholine headgroup, arrange themselves to maximize contact between the polyunsaturated chain and the protein surface. This organization is driven by energetically favorable interactions between the transmembrance helices and the docosohexaenoyl chains that are largely of the van der Waals type. These observations are consistent with various experimental studies on rhodopsin and other G-protein coupled receptors and with the picture of extreme flexibility in polyunsaturated fatty acid chains that has arisen from recent NMR and computational work.

Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid. Publishing Authors By Initials

SE Feller,K Gawrisch,TB Woolf,

For similar natural sciences: physics: thermodynamics research abstracts see: natural sciences: physics: thermodynamics research

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Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 4434-5

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 16

MONTH: Apr

YEAR: 2003

Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid. Keywords Mesh Terms:

KEYWORDS: Thermodynamics

MESH TERMS: chemistry

Chemical & Substance for Abstract: Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid. Information

Substance Name: Rhodopsin

Registry Number: 9009-81-8

Grant and Affiliation Information for Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid.

AFFILIATION: Department of Chemistry, Wabash College, 301 West Wabash, Crawfordsville, IN 47933, USA. fellers@wabash.edu

Country: United States

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MEDLINETA: J Am Chem Soc

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