Rhabdastrellic acid-A inhibited PI3K/Akt pathway and induced apoptosis in human leukemia HL-60 cells.

Rhabdastrellic acid-A inhibited PI3K/Akt pathway and induced apoptosis in human leukemia HL-60 cells. Research Abstract Details 

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Rhabdastrellic acid-A inhibited PI3K/Akt pathway and induced apoptosis in human leukemia HL-60 cells. Abstract Text:

Jing-Feng Guo,Jun-Min Zhou,Yong Zhang,Rong Deng,Jian-Nan Liu,Gong-Kan Feng,Zong-Chao Liu,Ding-Jun Xiao,Song-Zhi Deng,Xiao-Feng Zhu,

Increasing evidence suggests that aberrant activation of PI3K/Akt is involved in many human cancers, and that inhibition of the PI3K/Akt pathway might be a promising strategy for cancer treatment. Our investigation indicates that Rhabdastrellic acid-A, an isomalabaricane triterpenoid isolated from the sponge, Rhabdastrella globostellata, inhibits proliferation of HL-60 cells with an IC(50) value of 0.68mug/ml, and induces apoptosis. Rhabdastrellic acid-A also induces cleavage of the death substrate poly (ADP-ribose) polymerase (PARP) and caspase-3. Pretreatment of HL-60 cells with the caspase-3 specific inhibitor, DEVD-CHO, prevents Rhabdastrellic acid-A-induced DNA fragmentation and PARP cleavage. Activated PI3K and Akt significantly decreases after treatment with Rhabdastrellic acid-A in HL-60 cells. Expression levels of protein bcl-2, bax remain unchanged in response to Rhabdastrellic acid-A treatment in HL-60 cells. These results suggest that Rhabdastrellic acid-A inhibits PI3K/Akt pathway and induces caspase-3 dependent-apoptosis in HL-60 human leukemia cells.

Rhabdastrellic acid-A inhibited PI3K/Akt pathway and induced apoptosis in human leukemia HL-60 cells. Publishing Authors By Initials

JF Guo,JM Zhou,Y Zhang,R Deng,JN Liu,GK Feng,ZC Liu,DJ Xiao,SZ Deng,XF Zhu,

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Rhabdastrellic acid-A inhibited PI3K/Akt pathway and induced apoptosis in human leukemia HL-60 cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell biology international

VOLUME: 32

Page Numbers: 48-54

Journal Abbreviation: Cell Biol. Int.

ISSN: 1065-6995

DAY: 1

MONTH: 09

YEAR: 2007

Rhabdastrellic acid-A inhibited PI3K/Akt pathway and induced apoptosis in human leukemia HL-60 cells. Information

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LANGUAGE: eng

NlmUniqueID: 9307129

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AFFILIATION: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, 651 Dongfeng Road East, Guangzhou 510060, P.R. China; Hexian Memorial Hospital,1 Qinghe Road East, Panyu District, Guangzhou 511400, P.R. China.

Country: England

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MEDLINETA: Cell Biol Int

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