Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism.

Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism. Research Abstract Details 

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Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism. Abstract Text:

Hao Liu,Angayarkanni Suresh,Francis S Willard,David P Siderovski,Shen Lu,Naweed I Naqvi,

Regulators of G-protein signaling (RGS proteins) negatively regulate heterotrimeric G-protein cascades that enable eukaryotic cells to perceive and respond to external stimuli. The rice-blast fungus Magnaporthe grisea forms specialized infection structures called appressoria in response to inductive surface cues. We isolated Magnaporthe RGS1 in a screen for mutants that form precocious appressoria on non-inductive surfaces. We report that a thigmotropic cue is necessary for initiating appressoria and for accumulating cAMP. Similar to an RGS1-deletion strain, magA(G187S) (RGS-insensitive Galpha(s)) and magA(Q208L) (GTPase-dead) mutants accumulated excessive cAMP and elaborated appressoria on non-inductive surfaces, suggesting that Rgs1 regulates MagA during pathogenesis. Rgs1 was also found to negatively regulate the Galpha(i) subunit MagB during asexual development. Deficiency of MAGB suppressed the hyper-conidiation defect in RGS1-deletion strain, whereas magB(G183S) and magB(Q204L) mutants produced more conidia, similar to the RGS1-deletion strain. Rgs1 physically interacted with GDP.AlF(4)(-)-activated forms of MagA, MagB and MagC (a Galpha(II) subunit). Thus, Rgs1 serves as a negative regulator of all Galpha subunits in Magnaporthe and controls important developmental events during asexual and pathogenic development.

Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism. Publishing Authors By Initials

H Liu,A Suresh,FS Willard,DP Siderovski,S Lu,NI Naqvi,

For similar biological phenomena, cell phenomena, and immunity: plant physiology: tropism research abstracts see: biological phenomena, cell phenomena, and immunity: plant physiology: tropism research

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Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The EMBO journal

VOLUME: 26

Page Numbers: 690-700

Journal Abbreviation: EMBO J.

ISSN: 0261-4189

DAY: 25

MONTH: 01

YEAR: 2007

Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8208664

Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism. Keywords Mesh Terms:

KEYWORDS: Tropism

MESH TERMS: physiology

Chemical & Substance for Abstract: Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism. Information

Substance Name: Cyclic AMP

Registry Number: 60-92-4

Grant and Affiliation Information for Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism.

AFFILIATION: Fungal Patho-Biology Group, Temasek Life Sciences Laboratory, National University of Singapore, Singapore.

Country: England

AGENCY: United States NIGMS

GRANT: R01 GM074268

ACRONYM: GM

MEDLINETA: EMBO J

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