[Rexetin in the therapy of depressive states]

[Rexetin in the therapy of depressive states] Research Abstract Details 

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[Rexetin in the therapy of depressive states] Abstract Text:

A S Bobrov,O V Petrun'ko,A V Kovaleva,O N Pavlova,

Rexetin was used in the dosage of 20-60 mg daily during 6 weeks in the treatment of 25 patients with depression. An efficacy of the therapy was evaluated by the Hamilton scales for Depression (HAM-D) and anxiety (HAM-A) and Montgomery-Asberg Scale (MADRS). Patients were considered as responders if they demonstrated the reduction of scores by 50%. Twenty-three responders (92.0%) were divided into 3 groups: the first--with immediate therapeutic response during 1-2 weeks (n = 8; 34.8%); the second--with positive dynamics at the 3rd week of the treatment (n = 9; 39.1%); the third group--with favorable results at the end of 5-6 week of the therapy (n = 6; 26.1%). The clinical predictors of different therapeutic responses during short-term therapy were as follows: severity of depressive episode, hypotimia of modality (anxiety, anxiety-sorrow); vitalization of verbal/ nonverbal sorrow affect; presentation of autonomic (somatic) appearances of generalized anxiety disorder; ranks of typical depressive symptoms in subjective perception of patients; character of sleep disorders, presence of atypical depressive symptoms, in particular a disturbance of interpersonal relations due to elevated irritability; localization and extent of generalization of pathological body sensations; dominant content of obsessive anxiety; a type of affective triad; panic attacks, with- or without agoraphobia, concomitant to depressive disorder. In the total group of responders, there was a simultant (harmonic) reduction of the total score on the depression and anxiety scales (65.2%) and the anticipating anxiolytic or thymoanaleptic effect of the drug was observed less often (34.8%).

[Rexetin in the therapy of depressive states] Publishing Authors By Initials

AS Bobrov,OV Petrun'ko,AV Kovaleva,ON Pavlova,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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[Rexetin in the therapy of depressive states] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsak

VOLUME: 105

Page Numbers: 30-4

Journal Abbreviation:

ISSN: 1997-7298

DAY: 31

MONTH: 03

YEAR: 2005

[Rexetin in the therapy of depressive states] Information

Number of References:

LANGUAGE: rus

NlmUniqueID: 9712194

[Rexetin in the therapy of depressive states] Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: [Rexetin in the therapy of depressive states] Information

Substance Name: Paroxetine

Registry Number: 61869-08-7

Grant and Affiliation Information for [Rexetin in the therapy of depressive states]

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Country: Russia (Federation)

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MEDLINETA: Zh Nevrol Psikhiatr Im S S Kor

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