Reversible dissociation of flavin mononucleotide from the mammalian membrane-bound NADH:ubiquinone oxidoreductase (complex I).

Reversible dissociation of flavin mononucleotide from the mammalian membrane-bound NADH:ubiquinone oxidoreductase (complex I). Research Abstract Details 

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Reversible dissociation of flavin mononucleotide from the mammalian membrane-bound NADH:ubiquinone oxidoreductase (complex I). Abstract Text:

Irina S Gostimskaya,Vera G Grivennikova,Gary Cecchini,Andrei D Vinogradov,Irina S Gostimskaya,Vera G Grivennikova,Gary Cecchini,Andrei D Vinogradov,

Conditions for the reversible dissociation of flavin mononucleotide (FMN) from the membrane-bound mitochondrial NADH:ubiquinone oxidoreductase (complex I) are described. The catalytic activities of the enzyme, i.e. rotenone-insensitive NADH:hexaammineruthenium III reductase and rotenone-sensitive NADH:quinone reductase decline when bovine heart submitochondrial particles are incubated with NADH in the presence of rotenone or cyanide at alkaline pH. FMN protects and fully restores the NADH-induced inactivation whereas riboflavin and flavin adenine dinucleotide do not. The data show that the reduction of complex I significantly weakens the binding of FMN to protein thus resulting in its dissociation when the concentration of holoenzyme is comparable with K(d) ( approximately 10(-8)M at pH 10.0).

Reversible dissociation of flavin mononucleotide from the mammalian membrane-bound NADH:ubiquinone oxidoreductase (complex I). Publishing Authors By Initials

IS Gostimskaya,VG Grivennikova,G Cecchini,AD Vinogradov,IS Gostimskaya,VG Grivennikova,G Cecchini,AD Vinogradov,

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Reversible dissociation of flavin mononucleotide from the mammalian membrane-bound NADH:ubiquinone oxidoreductase (complex I). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: FEBS letters

VOLUME: 581

Page Numbers: 5803-6

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 26

MONTH: 11

YEAR: 2007

Reversible dissociation of flavin mononucleotide from the mammalian membrane-bound NADH:ubiquinone oxidoreductase (complex I). Information

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LANGUAGE: eng

NlmUniqueID: 155157

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Grant and Affiliation Information for Reversible dissociation of flavin mononucleotide from the mammalian membrane-bound NADH:ubiquinone oxidoreductase (complex I).

AFFILIATION: Department of Biochemistry, School of Biology, Moscow State University, Moscow 119992, Russian Federation.

Country: Netherlands

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MEDLINETA: FEBS Lett

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