Reverse structure of carnosine-induced sedative and hypnotic effects in the chick under acute stress.

Reverse structure of carnosine-induced sedative and hypnotic effects in the chick under acute stress. Research Abstract Details 

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Reverse structure of carnosine-induced sedative and hypnotic effects in the chick under acute stress. Abstract Text:

In the central nervous system, beta-alanine is thought to act as an inhibitory neurotransmitter, but the role or precise mechanism of beta-alanine in the brain has not been clearly defined. beta-Alanine is found in high levels in the chicken brain as a component of the dipeptides carnosine (beta-alanyl-l-histidine) and anserine, or as a free amino acid. We focused on the position of beta-alanine, i.e., at the carboxyl terminus. In Experiment 1, the central effects of glycyl-beta-alanine, l-histidyl-beta-alanine and l-valyl-beta-alanine were compared with a saline control in chicks. l-Histidyl-beta-alanine significantly induced sedative and hypnotic effects. In Experiment 2, the effects of carnosine, its reverse (l-histidyl-beta-alanine), and their combination were investigated. Central carnosine-induced hyperactivity while reverse carnosine-induced hypoactivity, and the behaviors were intermediate following the combination of the two peptides. Finally, the central effect of reverse carnosine was compared with beta-alanine alone and l-seryl-beta-alanine in Experiment 3. Reverse carnosine showed similar effects to beta-alanine. In conclusion, l-histidyl-beta-alanine not only has the reverse structure of carnosine, but also reverse function. Thus, we propose to name reverse carnosine (l-histidyl-beta-alanine) rev-carnosine.

Reverse structure of carnosine-induced sedative and hypnotic effects in the chick under acute stress. Publishing Authors By Initials

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Reverse structure of carnosine-induced sedative and hypnotic effects in the chick under acute stress. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Life sciences

VOLUME: 82

Page Numbers: 1065-9

Journal Abbreviation: Life Sci.

ISSN: 0024-3205

DAY: 3

MONTH: 04

YEAR: 2008

Reverse structure of carnosine-induced sedative and hypnotic effects in the chick under acute stress. Information

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LANGUAGE: eng

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AFFILIATION: Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.

Country: England

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MEDLINETA: Life Sci

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