Reverse-Remodeling Effects of Angiotensin II Type 1 Receptor Blocker in a Canine Atrial Fibrillation Model.

Reverse-Remodeling Effects of Angiotensin II Type 1 Receptor Blocker in a Canine Atrial Fibrillation Model. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Reverse-Remodeling Effects of Angiotensin II Type 1 Receptor Blocker in a Canine Atrial Fibrillation Model. Abstract Text:

Hideko Nakashima,Koichiro Kumagai,Hideko Nakashima,Koichiro Kumagai,Hideko Nakashima,Koichiro Kumagai,

Background The reverse-remodeling effect of angiotensin II type 1 receptor blocker (ARB) on atrial fibrillation (AF) is unclear. Methods and Results Sustained AF was induced in 20 dogs by 4-week rapid atrial pacing. The AF duration, atrial effective refractory period (AERP) and intra-atrial conduction time (CT) were measured every 2 weeks. After 4-week pacing, dogs were randomly assigned to control (n=10) and ARB (olmesartan; n=10) groups. Olmesartan was administered orally (3 mg . kg(-1) . day(-1)) after pacing was terminated, and continued for the 4-week recovery period. After 4-week pacing, AERP shortening, CT prolongation and AF maintenance were not significantly different between the 2 groups. During the recovery, AERP recovered to baseline in both groups. CT remained prolonged in the control group during the recovery, but recovered to baseline in the olmesartan group. The mean AF duration in the olmesartan group after 4-week-recovery was significantly shorter than that in the control group (58+/-20 vs 1,337+/-226 s, p<0.001). Olmesartan significantly decreased interstitial fibrosis compared with the control group (9+/-1% vs 15+/-1 at the right atrial appendage, p<0.001). Conclusion Olmesartan has a reverse-remodeling effect on AF-induced structural changes, indicating that it may be useful for preventing AF recurrence after the termination of sustained AF. (Circ J 2007; 71: 1977 - 1982).

Reverse-Remodeling Effects of Angiotensin II Type 1 Receptor Blocker in a Canine Atrial Fibrillation Model. Publishing Authors By Initials

H Nakashima,K Kumagai,H Nakashima,K Kumagai,H Nakashima,K Kumagai,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Reverse-Remodeling Effects of Angiotensin II Type 1 Receptor Blocker in a Canine Atrial Fibrillation Model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Circulation journal : official journal of the Japa

VOLUME: 71

Page Numbers: 1977-82

Journal Abbreviation: Circ. J.

ISSN: 1346-9843

DAY: 26

MONTH: Dec

YEAR: 2007

Reverse-Remodeling Effects of Angiotensin II Type 1 Receptor Blocker in a Canine Atrial Fibrillation Model. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101137683

Reverse-Remodeling Effects of Angiotensin II Type 1 Receptor Blocker in a Canine Atrial Fibrillation Model. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Reverse-Remodeling Effects of Angiotensin II Type 1 Receptor Blocker in a Canine Atrial Fibrillation Model. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Reverse-Remodeling Effects of Angiotensin II Type 1 Receptor Blocker in a Canine Atrial Fibrillation Model.

AFFILIATION: Department of Cardiology, Fukuoka University.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Circ J

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Reverse-Remodeling Effects of Angiotensin II Type 1 Receptor Blocker in a Canine Atrial Fibrillation Model Related Publications

• A case of cutaneous myiasis due to Dermatobia hominis in Japan.
• A fragile web of understanding.
• A protease inhibitor produced by Streptomyces lividans 66 exhibits inhibitory activities toward both subtilisin BPN' and trypsin.
• Anti-Atherogenic Action of Panax ginseng in Rats and in Patients with Hyperlipidemia.
• Calcium sensitivity of sea urchin tubulin in in vitro assembly and the effects of calcium-dependent regulator (CDR) proteins isolated from sea urchin eggs and porcine brains.
• Chemical Knockdown of Protein-tyrosine Phosphatase 1B by 1,2-Naphthoquinone through Covalent Modification Causes Persistent Transactivation of Epidermal Growth Factor Receptor.
• Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity.
• Effect of site-directed mutations on processing and activity of gamma-glutamyltranspeptidase of Escherichia coli K-12.
• Effects of ionic strength, substrate and pH on inactivation of heavy meromyosin caused by low concentrations of urea.
• Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice.
• Efficient construction of a diabody using a refolding system: anti-carcinoembryonic antigen recombinant antibody fragment.
• Enzymatic syntheses of T antigen-containing glycolipid mimicry using the transglycosylation activity of endo-alpha-N-acetylgalactosaminidase.
• Functional construction of the anti-mucin core protein (MUC1) antibody MUSE11 variable regions in a bacterial expression system.
• Gastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: immunohistochemical analysis of 136 lesions.
• Grafting of material-binding function into antibodies Functionalization by peptide grafting.
• Humanization of the bispecific epidermal growth factor receptor x CD3 diabody and its efficacy as a potential clinical reagent.
• Isochronous storage ring of the New SUBARU project.
• LPT1 Encodes a Membrane-bound O-Acyltransferase Involved in the Acylation of Lysophospholipids in the Yeast Saccharomyces cerevisiae.
• Microdose clinical trial: quantitative determination of fexofenadine in human plasma using liquid chromatography/electrospray ionization tandem mass spectrometry.
• Molecular modification of a novel macroporous silica-based impregnated polymeric composite by tri-n-butyl phosphate and its application in the adsorption for some metals contained in a typical simulated HLLW.
• Overestimation of serum levels of rheumatoid factor caused by the presence of an incorrect calibrator in the Dade Behring kit.
• Panning of a phage VH library using nitrocellulose membranes: application to selection of a human VH library.
• Reverse-Remodeling Effects of Angiotensin II Type 1 Receptor Blocker in a Canine Atrial Fibrillation Model.
• Role of phospholipid in adrenaline-induced lipolysis and cyclic AMP production.
• Simplified nutritional screening tools for patients on maintenance hemodialysis.
• Subunit association of gamma-glutamyltranspeptidase of Escherichia coli K-12.
• Thioredoxin may exert a protective effect against tissue damage caused by oxidative stress in salivary glands of Patients with Sjögren's syndrome.
• Upstream therapy for atrial fibrillation.
• [Chemical biology of 1,2-naphthoquinone, a novel air pollutant, that affects signal transduction pathways]
• [Glucocorticoid-induced osteoporosis in collagen vascular disease]