Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.

Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Research Abstract Details 

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Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Abstract Text:

Lei Yin,Nan Wu,Joshua C Curtin,Mohammed Qatanani,Nava R Szwergold,Robert A Reid,Gregory M Waitt,Derek J Parks,Kenneth H Pearce,G Bruce Wisely,Mitchell A Lazar,Lei Yin,Nan Wu,Joshua C Curtin,Mohammed Qatanani,Nava R Szwergold,Robert A Reid,Gregory M Waitt,Derek J Parks,Kenneth H Pearce,G Bruce Wisely,Mitchell A Lazar,

The circadian clock temporally coordinates metabolic homeostasis in mammals. Central to this is heme, an iron-containing porphyrin that serves as prosthetic group for enzymes involved in oxidative metabolism as well as transcription factors that regulate circadian rhythmicity. The circadian factor that integrates this dual function of heme is not known. We show that heme binds reversibly to the orphan nuclear receptor Rev-erbalpha, a critical negative component of the circadian core clock, and regulates its interaction with a nuclear receptor corepressor complex. Furthermore, heme suppresses hepatic gluconeogenic gene expression and glucose output through Rev-erbalpha-mediated gene repression. Thus, Rev-erbalpha serves as a heme sensor that coordinates the cellular clock, glucose homeostasis, and energy metabolism.

Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Publishing Authors By Initials

L Yin,N Wu,JC Curtin,M Qatanani,NR Szwergold,RA Reid,GM Waitt,DJ Parks,KH Pearce,GB Wisely,MA Lazar,L Yin,N Wu,JC Curtin,M Qatanani,NR Szwergold,RA Reid,GM Waitt,DJ Parks,KH Pearce,GB Wisely,MA Lazar,

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Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Science (New York, N.Y.)

VOLUME: 318

Page Numbers: 1786-9

Journal Abbreviation: Science

ISSN: 1095-9203

DAY: 15

MONTH: 11

YEAR: 2007

Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Information

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LANGUAGE: eng

NlmUniqueID: 404511

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Grant and Affiliation Information for Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.

AFFILIATION: Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK45586

ACRONYM: DK

MEDLINETA: Science

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