Retrograde suppression of GABAergic currents in a subset of SCN neurons.

Retrograde suppression of GABAergic currents in a subset of SCN neurons. Research Abstract Details 

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Retrograde suppression of GABAergic currents in a subset of SCN neurons. Abstract Text:

Heinrich S Gompf,Robert P Irwin,Charles N Allen,

Many postsynaptic neurons release a retrograde transmitter that modulates presynaptic neurotransmitter release. In the suprachiasmatic nucleus (SCN), retrograde signaling is suggested by the presence of dendritic dense-core vesicles. Whole-cell voltage-clamp recordings were made from rat SCN neurons to determine whether a retrograde messenger could modulate the activity of afferent gamma-aminobutyric acid (GABA)ergic inputs. The frequency and amplitude of spontaneous GABAergic currents was significantly reduced in a subpopulation of SCN neurons (eight out of 13) following a postsynaptic depolarization. Similarly, a postsynaptic depolarization significantly reduced the amplitude of evoked GABAergic currents during both day and night recordings. A postsynaptic depolarizing pulse eliminated paired-pulse inhibition of GABAergic currents consistent with a presynaptic mechanism. Muscimol-activated currents were not altered by postsynaptic depolarization, demonstrating that the activity of GABA(A) receptors was not altered. Depolarization-induced inhibition of the GABAergic currents was not observed when a Ca2+ chelator was included in the microelectrode. Postsynaptic depolarization significantly increased the Ca2+ concentration in both the soma and dendrites. The dendritic Ca2+ levels increased faster, to a higher concentration and decayed faster than in the soma. The depolarization-induced inhibition of the evoked GABAergic current was blocked by the G-protein uncoupling agent N-ethylmaleimide, suggesting that the retrograde messenger acts on a pertussis toxin-sensitive G-protein-coupled receptor. Because the majority of SCN neurons receive GABAergic input from neighboring cells, these results describe a retrograde signaling mechanism by which SCN neurons can modulate GABAergic synaptic input.

Retrograde suppression of GABAergic currents in a subset of SCN neurons. Publishing Authors By Initials

HS Gompf,RP Irwin,CN Allen,

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research

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Retrograde suppression of GABAergic currents in a subset of SCN neurons. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The European journal of neuroscience

VOLUME: 23

Page Numbers: 3209-16

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 0953-816X

DAY: 3

MONTH: Jun

YEAR: 2006

Retrograde suppression of GABAergic currents in a subset of SCN neurons. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8918110

Retrograde suppression of GABAergic currents in a subset of SCN neurons. Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: metabolism

Chemical & Substance for Abstract: Retrograde suppression of GABAergic currents in a subset of SCN neurons. Information

Substance Name: Calcium

Registry Number: 7440-70-2

Grant and Affiliation Information for Retrograde suppression of GABAergic currents in a subset of SCN neurons.

AFFILIATION: Center for Research on Occupational and Environmental Toxicology and Department of Physiology and Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

Country: France

AGENCY: United States NINDS

GRANT: NS40728

ACRONYM: NS

MEDLINETA: Eur J Neurosci

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