Retinyl Ester Homeostasis in the Adipose Differentiation-related Protein-deficient Retina.

Retinyl Ester Homeostasis in the Adipose Differentiation-related Protein-deficient Retina. Research Abstract Details 

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Retinyl Ester Homeostasis in the Adipose Differentiation-related Protein-deficient Retina. Abstract Text:

The retinal pigmented epithelium (RPE) plays an essential role in vision, including storing and converting retinyl esters of the visual chromophore, 11-cis-retinal. Retinyl ester storage structures (RESTs), specialized lipid droplets within the RPE, take up retinyl esters synthesized in the endoplasmic reticulum. Here we report studies of mice lacking exons 2 and 3 of the gene encoding adipose differentiation-related protein (Adfp), a structural component of RESTs. We found that dark adaptation was slower in Adfp(Delta2-3/Delta2-3) than in Adfp(+/+) mice and that Adfp(Delta2-3/Delta2-3) mice had consistently delayed clearances of all-trans-retinal and all-trans-retinol from rod photoreceptor cells. Two-photon microscopy revealed aberrant trafficking of all-trans-retinyl esters in the RPE of Adfp(Delta2-3/Delta2-3) mice, a problem caused by abnormal maintenance of RESTs in the dark-adapted state. Retinyl ester accumulation was also reduced in Adfp(Delta2-3/Delta2-3) as compared with Adfp(+/+) mice. These observations suggest that Adfp plays a unique role in vision by maintaining proper storage and trafficking of retinoids within the eye.

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Retinyl Ester Homeostasis in the Adipose Differentiation-related Protein-deficient Retina. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of biological chemistry

VOLUME: 283

Page Numbers: 25091-102

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 7

MONTH: 07

YEAR: 2008

Retinyl Ester Homeostasis in the Adipose Differentiation-related Protein-deficient Retina. Information

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LANGUAGE: eng

NlmUniqueID: 2985121

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Grant and Affiliation Information for Retinyl Ester Homeostasis in the Adipose Differentiation-related Protein-deficient Retina.

AFFILIATION: Department of Pharmacology and Department of Ophthalmology, Case Western Reserve University, Cleveland, Ohio 44106.

Country: United States

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MEDLINETA: J Biol Chem

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