Retinoblastoma protein regulation by the COP9 signalosome.

Retinoblastoma protein regulation by the COP9 signalosome. Research Abstract Details 

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Retinoblastoma protein regulation by the COP9 signalosome. Abstract Text:

Zakir Ullah,Martin S Buckley,David N Arnosti,R William Henry,

Similar to their human counterparts, the Drosophila Rbf1 and Rbf2 Retinoblastoma family members control cell cycle and developmentally regulated gene expression. Increasing evidence suggests that Rbf proteins rely on multiprotein complexes to control target gene transcription. We show here that the developmentally regulated COP9 signalosome (CSN) physically interacts with Rbf2 during embryogenesis. Furthermore, the CSN4 subunit of the COP9 signalosome co-occupies Rbf target gene promoters with Rbf1 and Rbf2, suggesting an active role for the COP9 signalosome in transcriptional regulation. The targeted knockdown of individual CSN subunits leads to diminished Rbf1 and Rbf2 levels and to altered cell cycle progression. The proteasome-mediated destruction of Rbf1 and Rbf2 is increased in cells and embryos with diminished COP9 activity, suggesting that the COP9 signalosome protects Rbf proteins during embryogenesis. Previous evidence has linked gene activation to protein turnover via the promoter-associated proteasome. Our findings suggest that Rbf repression may similarly involve the proteasome and the promoter-associated COP9 signalosome, serving to extend Rbf protein lifespan and enable appropriate programs of retinoblastoma gene control during development.

Retinoblastoma protein regulation by the COP9 signalosome. Publishing Authors By Initials

Z Ullah,MS Buckley,DN Arnosti,RW Henry,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

PUBMED ID PMID:

MEDLINE DATE:

Retinoblastoma protein regulation by the COP9 signalosome. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular biology of the cell

VOLUME: 18

Page Numbers: 1179-86

Journal Abbreviation: Mol. Biol. Cell

ISSN: 1059-1524

DAY: 24

MONTH: 01

YEAR: 2007

Retinoblastoma protein regulation by the COP9 signalosome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9201390

Retinoblastoma protein regulation by the COP9 signalosome. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Retinoblastoma protein regulation by the COP9 signalosome. Information

Substance Name: Proteasome Endopeptidase Complex

Registry Number: EC 3.4.25.1

Grant and Affiliation Information for Retinoblastoma protein regulation by the COP9 signalosome.

AFFILIATION: Department of Biochemistry and Molecular Biology and Genetics Program, Michigan State University, East Lansing, MI 48824, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM59805

ACRONYM: GM

MEDLINETA: Mol Biol Cell

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