Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes.

Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes. Research Abstract Details 

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Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes. Abstract Text:

Jiyun Ahn,Hyunjung Lee,Suna Kim,Taeyoul Ha,Jiyun Ahn,Hyunjung Lee,Suna Kim,Taeyoul Ha,

Tumor necrosis factor-alpha (TNF-alpha) is chronically elevated in adipose tissues of obese rodents and humans. Increased levels of TNF-alpha are implicated in the induction of atherogenic adipokines, such as plasminogen activator inhibitor -1 (PAI-1) and IL-6, and the inhibition of the anti-atherogenic adipokine, adiponectin. In this study, we investigated the effects of resveratrol on TNF-alpha-induced atherogenic changes of the adipokines in 3T3-L1 cells. Exposure to TNF-alpha for 24 h increased PAI-1 and IL-6 secretion and decreased adiponectin secretion. The mRNA expression of adipokines changed in parallel with mRNA expression. Resveratrol effectively reversed the secretion and mRNA expression of the atherogenic adipokines, PAI-1 and IL-6, induced by TNF-alpha. Decreased secretion levels and mRNA expression of adiponectin by TNF-alpha were also recovered by resveratrol treatment. Our results suggest that resveratrol may improve obesity-induced cardiovascular disease, particularly atherosclerosis, by attenuating the TNF-alpha-induced changes of adipokines.

Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes. Publishing Authors By Initials

J Ahn,H Lee,S Kim,T Ha,J Ahn,H Lee,S Kim,T Ha,

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Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 364

Page Numbers: 972-7

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 29

MONTH: 10

YEAR: 2007

Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes. Information

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LANGUAGE: eng

NlmUniqueID: 372516

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AFFILIATION: Food Function Research Group, Korea Food Research Institute, 516, Baekhyun-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-746, Republic of Korea.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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