Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells.

Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells. Research Abstract Details 

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Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells. Abstract Text:

Jong-Wook Park,Kyung Jin Woo,Jung-Tae Lee,Jun Hee Lim,Tae-Jin Lee,Sang Hyun Kim,Yung Hyun Choi,Taeg Kyu Kwon,Jong-Wook Park,Kyung Jin Woo,Jung-Tae Lee,Jun Hee Lim,Tae-Jin Lee,Sang Hyun Kim,Yung Hyun Choi,Taeg Kyu Kwon,

Resveratrol (3,4',5 tri-hydroxystilbene), a naturally occurring polyphenolic compound highly enriched in grapes and red wine, has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. Resveratrol-induced dose-dependent apoptotic cell death in colon carcinoma cells, was measured by FACS analysis. Treatment of HT29 human colon carcinoma cells with resveratrol was found to induce a number of signature ER stress markers; phosphorylation of eukaryotic initiation factor-2alpha (eIF-2alpha), ER stress-specific XBP1 splicing and CCAAT/enhancer-binding protein-homologous protein (CHOP). In addition, resveratrol induced up-regulation of glucose-regulated protein (GRP)-78, suggesting the induction of ER stress. Furthermore, the inhibition of caspase-4 activity by z-LEVD-fmk significantly reduced resveratrol-induced apoptosis. Taken together, the present study therefore provides strong evidence to support an important role of ER stress response in mediating the resveratrol-induced apoptosis.

Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells. Publishing Authors By Initials

JW Park,KJ Woo,JT Lee,JH Lim,TJ Lee,SH Kim,YH Choi,TK Kwon,JW Park,KJ Woo,JT Lee,JH Lim,TJ Lee,SH Kim,YH Choi,TK Kwon,

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Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Oncology reports

VOLUME: 18

Page Numbers: 1269-73

Journal Abbreviation: Oncol. Rep.

ISSN: 1021-335X

DAY: 4

MONTH: Nov

YEAR: 2007

Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells. Information

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LANGUAGE: eng

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AFFILIATION: Department of Immunology and Chronic Disease Research Center and Institute for Medical Science, School of Medicine, Keimyung University, 194 DingSan-Dong Jung-Gu, Taegu 700-712, South Korea.

Country: Greece

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MEDLINETA: Oncol Rep

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