Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways.

Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Research Abstract Details 

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Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Abstract Text:

Coers,Russell E Vance,Mary F Fontana,William F Dietrich,

Macrophages from the C57BL/6 (B6) mouse strain restrict intracellular growth of Legionella pneumophila, whereas A/J macrophages are highly permissive. The mechanism by which B6 macrophages restrict Legionella growth remains poorly understood, but is known to require the cytosolic microbe sensors Naip5 (Birc1e) and Ipaf. We hypothesized that Naip5 and Ipaf may act in partnership with other antimicrobial signalling pathways in macrophages. Indeed, we found that macrophages lacking either tumour necrosis factor (TNF)-alpha or type I interferon (IFN) signalling are permissive for growth of L. pneumophila, even in the presence of functional Naip5 and Ipaf alleles. Similarly, macrophages lacking Naip5 and/or Ipaf signalling were permissive even though we found that Naip5 or Ipaf were not required for induction of TNF-alpha and type I IFN. Therefore, our data suggest that the mechanism by which B6 macrophages restrict intracellular replication of L. pneumophila is more complex than previously appreciated, and involves the concerted action of cytokine and intracellular microbe sensor signalling pathways.

Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Publishing Authors By Initials

J Coers,RE Vance,MF Fontana,WF Dietrich,

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Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cellular microbiology

VOLUME: 9

Page Numbers: 2344-57

Journal Abbreviation: Cell. Microbiol.

ISSN: 1462-5814

DAY: 15

MONTH: 05

YEAR: 2007

Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways.

AFFILIATION: Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. jcoers@genetics.med.harvard.edu

Country: England

AGENCY: United States NIAID

GRANT: R01 AI062827

ACRONYM: AI

MEDLINETA: Cell Microbiol

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