[Restenosed growth of plaque cells from restenosed peripheral and coronary plaque material of the human in vitro: a correlation to animal experiment results following angioplasty]

[Restenosed growth of plaque cells from restenosed peripheral and coronary plaque material of the human in vitro: a correlation to animal experiment results following angioplasty] Research Abstract Details 

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[Restenosed growth of plaque cells from restenosed peripheral and coronary plaque material of the human in vitro: a correlation to animal experiment results following angioplasty] Abstract Text:

R Voisard,P C Dartsch,U Seitzer,A Hannekum,V Hombach,E Betz,

In this study cells were isolated from primary-stenosing and re-stenosing tissue of human peripheral (extraction by Prof. Höfling and Dr. Bauriedel, Munich) and coronary arteries. The vast majority of plaque cells was identified as smooth muscle cells (SMC) by positive reaction with monoclonal antibodies against smooth muscle alpha-Actin. All SMC consisted of two different subpopulations, which were discriminated by different cell diameters: Relatively small cells (diameter: 18.0 +/- 4 microns, mean +/- SD) and large cells (diameter: 26.0 +/- 3 microms, mean +/- SD). Population doublings per day (PD/day) for SMC from re-stenosing lesions were significantly increased (0.60 +/- 0.13 PD/day, mean +/- SD) in comparison to SMC from primary-stenosing lesions (0.15 +/- 0.04 PD/day, mean +/- SD), p much less than 0.001). Thus, the increased growth of SMC from restenosing lesions in vitro might be the equivalent to the rapid progression of restenosing events after angioplasty in vivo. These results are in accordance with data from experimental studies after angioplasty.

[Restenosed growth of plaque cells from restenosed peripheral and coronary plaque material of the human in vitro: a correlation to animal experiment results following angioplasty] Publishing Authors By Initials

R Voisard,PC Dartsch,U Seitzer,A Hannekum,V Hombach,E Betz,

For similar pathological conditions, signs and symptoms: pathologic processes: disease attributes: recurrence research abstracts see: pathological conditions, signs and symptoms: pathologic processes: disease attributes: recurrence research

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[Restenosed growth of plaque cells from restenosed peripheral and coronary plaque material of the human in vitro: a correlation to animal experiment results following angioplasty] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: VASA. Supplementum

VOLUME: 33

Page Numbers: 135-7

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ISSN: 0251-1029

DAY: 21

MONTH: 02

YEAR: 1991

[Restenosed growth of plaque cells from restenosed peripheral and coronary plaque material of the human in vitro: a correlation to animal experiment results following angioplasty] Information

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LANGUAGE: ger

NlmUniqueID: 8704474

[Restenosed growth of plaque cells from restenosed peripheral and coronary plaque material of the human in vitro: a correlation to animal experiment results following angioplasty] Keywords Mesh Terms:

KEYWORDS: Recurrence

MESH TERMS: pathology

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Grant and Affiliation Information for [Restenosed growth of plaque cells from restenosed peripheral and coronary plaque material of the human in vitro: a correlation to animal experiment results following angioplasty]

AFFILIATION: Physiologisches Institut I, Universität Tübingen.

Country: SWITZERLAND

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MEDLINETA: Vasa Suppl

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