Responses of presumed cholinergic mesopontine tegmental neurons to carbachol microinjections in freely moving cats.

Responses of presumed cholinergic mesopontine tegmental neurons to carbachol microinjections in freely moving cats. Research Abstract Details 

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Responses of presumed cholinergic mesopontine tegmental neurons to carbachol microinjections in freely moving cats. Abstract Text:

M el Mansari,K Sakai,M Jouvet,

The effects of microinjections of a cholinergic agonist, carbachol (0.2 microgram/0.2 microliter), were examined on three different types of rostrally projecting tonic neurons that we have reported previously in the dorsal part of the pontomesencephalic tegmentum known to contain numerous cholinergic cell bodies: 1) tonic type I slow (Type I-S); 2) tonic type I rapid (Type I-R); and 3) tonic type II (Type II) (El Mansari et al. 1989). Microinjections of carbachol near unit recording sites in freely moving cats induced within a few minutes a complete suppression of the spontaneous activity and a marked reduction in orthodromic excitation of identified and non-identified type I-S neurons. These effect lasted for approximately 90-120 min and were reversed by local (0.4 microgram/0.2 microliter) or systemic (0.1-0.2 mg/kg, i.m.) administration of atropine sulfate. In contrast, the cholinergic agonist had no consistent effects on tonic type II nor on tonic type I-R neurons. In the light of these and other recent findings, we suggested the direct inhibition of central cholinergic neurons via muscarinic receptors, on the one hand, and the cholinergic nature of type I-S, but not type I-R nor type II neurons, on the other.

Responses of presumed cholinergic mesopontine tegmental neurons to carbachol microinjections in freely moving cats. Publishing Authors By Initials

M el Mansari,K Sakai,M Jouvet,

For similar nervous system: central nervous system: brain: brain stem: mesencephalon: tegmentum mesencephali research abstracts see: nervous system: central nervous system: brain: brain stem: mesencephalon: tegmentum mesencephali research

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Responses of presumed cholinergic mesopontine tegmental neurons to carbachol microinjections in freely moving cats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 83

Page Numbers: 115-23

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1990

Responses of presumed cholinergic mesopontine tegmental neurons to carbachol microinjections in freely moving cats. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Responses of presumed cholinergic mesopontine tegmental neurons to carbachol microinjections in freely moving cats. Keywords Mesh Terms:

KEYWORDS: Tegmentum Mesencephali

MESH TERMS: physiology

Chemical & Substance for Abstract: Responses of presumed cholinergic mesopontine tegmental neurons to carbachol microinjections in freely moving cats. Information

Substance Name: Carbachol

Registry Number: 51-83-2

Grant and Affiliation Information for Responses of presumed cholinergic mesopontine tegmental neurons to carbachol microinjections in freely moving cats.

AFFILIATION: Département de Médecine Expérimentale, INSERM U 52, CNRS-UA 1195, Université Claude Bernard, Lyon, France.

Country: GERMANY

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MEDLINETA: Exp Brain Res

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