Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4).

Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4). Research Abstract Details 

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Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4). Abstract Text:

Jacqueline E Calvano,Daniel J Bowers,Susette M Coyle,Marie Macor,Michael T Reddell,Ashwini Kumar,Steve E Calvano,Stephen F Lowry,

Mutations (Asp299Gly and Thr399Ile) in the human Toll-like receptor 4 (hTLR4) gene are reportedly associated with hyporesponsiveness to inhaled LPS in humans. It was hypothesized that normal volunteers with these hTLR4 mutations would manifest altered physiological responses to intravenous LPS administration. Human subjects (n = 57) were administered LPS (2 ng/kg) intravenously and monitored for vital signs (temperature, heart rate, mean arterial pressure). Blood-derived genomic DNA samples were evaluated using PCR to detect hTLR4 and TLR2 mutations. Heterozygous hTLR4 mutations were identified in 8 of the 57 subjects studied. Subjects with hTLR4 mutations demonstrated similar responses to LPS administration. The moderate systemic inflammatory response produced by intravenous LPS administration in human subjects is not modulated by the presence of heterozygous mutations in the hTLR4 gene.

Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4). Publishing Authors By Initials

JE Calvano,DJ Bowers,SM Coyle,M Macor,MT Reddell,A Kumar,SE Calvano,SF Lowry,

For similar proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, pattern recognition: toll-like receptors: toll-like receptor 4 research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, pattern recognition: toll-like receptors: toll-like receptor 4 research

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Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4). Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Clinical immunology (Orlando, Fla.)

VOLUME: 121

Page Numbers: 186-90

Journal Abbreviation: Clin. Immunol.

ISSN: 1521-6616

DAY: 7

MONTH: 07

YEAR: 2006

Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100883537

Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4). Keywords Mesh Terms:

KEYWORDS: Toll-Like Receptor 4

MESH TERMS: genetics

Chemical & Substance for Abstract: Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4). Information

Substance Name: Toll-Like Receptor 4

Registry Number: 0

Grant and Affiliation Information for Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4).

AFFILIATION: Division of Surgical Sciences, Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, CAB 7300, 125 Paterson Street, New Brunswick, NJ 08903, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM34695

ACRONYM: GM

MEDLINETA: Clin Immunol

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