Response of olfactory axons to loss of synaptic targets in the adult mouse.

Response of olfactory axons to loss of synaptic targets in the adult mouse. Research Abstract Details 

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Response of olfactory axons to loss of synaptic targets in the adult mouse. Abstract Text:

Yona Ardiles,Rafael de la Puente,Rafael Toledo,Ceylan Isgor,Kathleen Guthrie,Yona Ardiles,Rafael de la Puente,Rafael Toledo,Ceylan Isgor,Kathleen Guthrie,

Glomerular convergence has been proposed to rely on interactions between like olfactory axons, however topographic targeting is influenced by guidance molecules encountered in the olfactory bulb. Disruption of these cues during development misdirects sensory axons, however little is known about the role of bulb-derived signals in later life, as new axons arise during turnover of the olfactory sensory neuron (OSN) population. To evaluate the contribution of bulb neurons in maintaining topographic projections in adults, we ablated them with N-methyl-d-aspartate (NMDA) in P2-IRES-tauLacZ mice and examined how sensory axons responded to loss of their postsynaptic partners. NMDA lesion eliminated bulb neurons without damage to sensory axons or olfactory ensheathing glia. P2 axons contained within glomeruli at the time of lesion maintained convergence at these locations; there was no evidence of compensatory growth into the remnant tissue. Delayed apoptosis of OSNs in the target-deprived epithelium led to declines in P2 neuron number as well as the gradual atrophy, and in some cases complete loss, of P2 glomeruli in lesioned bulbs by 3 weeks. Increased cell proliferation in the epithelium partially restored the OSN population, and by 8 weeks, new P2 axons distributed within diverse locations in the bulb remnant and within the anterior olfactory nucleus. Prior studies have suggested that initial development of olfactory topography does not rely on synapse formation with target neurons, however the present data demonstrate that continued maintenance of the sensory map requires the presence of sufficient numbers and/or types of available bulbar synaptic targets.

Response of olfactory axons to loss of synaptic targets in the adult mouse. Publishing Authors By Initials

Y Ardiles,R de la Puente,R Toledo,C Isgor,K Guthrie,Y Ardiles,R de la Puente,R Toledo,C Isgor,K Guthrie,

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Response of olfactory axons to loss of synaptic targets in the adult mouse. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Experimental neurology

VOLUME: 207

Page Numbers: 275-88

Journal Abbreviation: Exp. Neurol.

ISSN: 0014-4886

DAY: 12

MONTH: 07

YEAR: 2007

Response of olfactory axons to loss of synaptic targets in the adult mouse. Information

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LANGUAGE: eng

NlmUniqueID: 370712

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Grant and Affiliation Information for Response of olfactory axons to loss of synaptic targets in the adult mouse.

AFFILIATION: BC 208, Department of Biomedical Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM073621

ACRONYM: GM

MEDLINETA: Exp Neurol

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