Response of monocytes exposed to phagocytosable particles and discs of comparable surface roughness.

Response of monocytes exposed to phagocytosable particles and discs of comparable surface roughness. Research Abstract Details 

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Response of monocytes exposed to phagocytosable particles and discs of comparable surface roughness. Abstract Text:

Dong-Hwan Kim,Matt T Novak,Jamie Wilkins,Minkyu Kim,Anita Sawyer,William M Reichert,

This in vitro study characterized the temporal cytokine expression profile from human monocytes exposed to phagocytosable Ti particles (0.78+/-0.12 microm) and to Ti discs of comparable surface roughness. Human THP-1 monocytes were cultured in six well tissue culture polystyrene (TCPS) plates. Each well was either bare, contained Ti particles (the particles were clearly engulfed by the monocytes), or contained a Ti disc. Half of the wells were treated with 1 microg/mL lipopolysaccharide (LPS), while the other half were left unstimulated. Unstimulated and LPS-stimulated cells in bare wells were the negative and positive controls, respectively. Supernatant was sampled from each well at 1, 6, 24, 48, and 72 h and assayed for the expression of nine different cytokines using a Luminex system. Three cytokines (IL-1beta, GM-CSF and IL-13) gave little to no response under all conditions, while six cytokines (TNF-alpha, IL-6, MIP-1alpha, MCP-1, VEGF, and IL-1ra) were clearly detectable. Expression levels generally increased with culture time, particle concentration, and LPS stimulation. Most significantly, it was found that cells treated by Ti discs produced in many instances a higher cytokine expression than did particles.

Response of monocytes exposed to phagocytosable particles and discs of comparable surface roughness. Publishing Authors By Initials

DH Kim,MT Novak,J Wilkins,M Kim,A Sawyer,WM Reichert,

For similar inorganic chemicals: elements: metals, light: titanium research abstracts see: inorganic chemicals: elements: metals, light: titanium research

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Response of monocytes exposed to phagocytosable particles and discs of comparable surface roughness. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biomaterials

VOLUME: 28

Page Numbers: 4231-9

Journal Abbreviation: Biomaterials

ISSN: 0142-9612

DAY: 12

MONTH: 07

YEAR: 2007

Response of monocytes exposed to phagocytosable particles and discs of comparable surface roughness. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8100316

Response of monocytes exposed to phagocytosable particles and discs of comparable surface roughness. Keywords Mesh Terms:

KEYWORDS: Titanium

MESH TERMS: chemistry

Chemical & Substance for Abstract: Response of monocytes exposed to phagocytosable particles and discs of comparable surface roughness. Information

Substance Name: Titanium

Registry Number: 7440-32-6

Grant and Affiliation Information for Response of monocytes exposed to phagocytosable particles and discs of comparable surface roughness.

AFFILIATION: Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Box 90281, Durham, NC 27708, USA.

Country: England

AGENCY: United States NIDDK

GRANT: DK054932

ACRONYM: DK

MEDLINETA: Biomaterials

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